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Effectiveness of umbilical cord mesenchymal stem cells in patients with critical limb ischemia / Efectividad de las células madre mesenquimales del cordón umbilical en pacientes con isquemia crítica de extremidades
Gao, Wen-Hui; Gao, Hong-Ye; Li, Yue-Tong; Huang, Ping-Ping.
Afiliação
  • Gao, Wen-Hui; Peking Union Medical College. Chinese Academy of Medical Sciences. Blood Diseases Hospital. General Medical Center. Institute of Hematology. Tianjin. China
  • Gao, Hong-Ye; Peking Union Medical College. Chinese Academy of Medical Sciences. Blood Diseases Hospital. General Medical Center. Institute of Hematology. Tianjin. China
  • Li, Yue-Tong; Tianjin University of Traditional Chinese Medicine. Tianjin. China
  • Huang, Ping-Ping; Peking Union Medical College. Chinese Academy of Medical Sciences. Blood Diseases Hospital. General Medical Center. Institute of Hematology. Tianjin. China
Med. clín (Ed. impr.) ; 153(9): 341-346, nov. 2019. ilus, graf, tab
Artigo em Inglês | IBECS | ID: ibc-186266
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Introduction and

objective:

Transplantation of umbilical cord mesenchymal stem cells (UC-MSCs) has been shown to be effective in treating critical limb ischemia (CLI). However, the mechanism of MSCs-mediated improvements, especially on the immune-inflammatory aspects of this disease, is still unknown. In this study, we investigated the changes in T-lymphocyte subpopulations and inflammatory mediators (such as IL-6, IL-10 and TNF-alpha) in PBMCs from CLI patients after UC-MSCs treatment and correlation between inflammatory mediators and EPCs. Patients and

methods:

8 patients received UC-MSCs transplantation. Before the treatment, at 24h and 1 month thereafter, peripheral blood samples were collected from 8 patients and 8 healthy volunteers. Patients were evaluated for changes in IL-6, IL-10, TNF-alpha and levels of circulating EPCs.

Results:

TNF-alpha and IL-6 serum levels increased at 24h (p=0.017, p=0.099) after treatment and then decreased at 1 month (p=0.031, p=0.072) compared with those before treatment. The percentages of CD3+T, CD3+CD4+T-lymphocytes and NK cells decreased significantly after UC-MSCs treatment (p=0.002, p=0.012 and p=0.029, respectively). TNF-alpha (r=−0.602, p=0.038) was shown to be inversely correlated with the number of circulating EPCs.

Conclusions:

This study demonstrates that UC-MSCs have anti-inflammatory and immunomodulation properties in CLI and suggests that UC-MSCs promote healing of non-healing wounds
RESUMEN
Introducción y

objetivo:

El trasplante de células madre mesenquimales del cordón umbilical (CMM-CU) ha demostrado eficacia en el tratamiento de la isquemia crítica de las extremidades (ICE). Sin embargo, se desconoce el mecanismo de las mejoras mediadas por las CMM, especialmente en los aspectos inmune-inflamatorios de esta enfermedad. Este estudio analiza los cambios en las subpoblaciones de linfocitos T y en los mediadores inflamatorios (como IL-6, IL-10 y TNF-alpha) en CMSP de pacientes con ICE después del tratamiento con CMM-CU y estudia la correlación entre mediadores inflamatorios y células progenitoras endoteliales (CPE). Pacientes y

métodos:

Ocho pacientes recibieron trasplante de CMM-CU. Se recogieron muestras de sangre periférica de 8 pacientes y 8 voluntarios sanos, antes del tratamiento, a las 24h y un mes después. Los pacientes fueron evaluados para detectar cambios en IL-6, IL-10, TNF-alpha y niveles de CPE circulantes.

Resultados:

Los niveles séricos de TNF-alpha e IL-6 aumentaron 24h después del tratamiento (p=0,017, p=0,099) y luego disminuyeron al mes (p=0,031, p=0,072) en comparación con los niveles antes del tratamiento. Los porcentajes de CD3+T, CD3+CD4+ linfocitos T y células NK disminuyeron significativamente después del tratamiento con CMM-CU (p=0,002, p=0,012 y p=0,029, respectivamente). TNF-alpha (r=−0,602, p=0,038) demostró estar correlacionada inversamente con el número de CPE circulantes.

Conclusiones:

Este estudio demuestra que las CMM-CU tienen propiedades antiinflamatorias e inmunomoduladoras en la ICE y sugieren que las CMM-CU promueven la curación de heridas que no cicatrizan
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Cordão Umbilical / Índice de Gravidade de Doença / Transplante de Células-Tronco Mesenquimais / Células Progenitoras Endoteliais / Isquemia Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Med. clín (Ed. impr.) Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Peking Union Medical College/China / Tianjin University of Traditional Chinese Medicine/China
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Cordão Umbilical / Índice de Gravidade de Doença / Transplante de Células-Tronco Mesenquimais / Células Progenitoras Endoteliais / Isquemia Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Med. clín (Ed. impr.) Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Peking Union Medical College/China / Tianjin University of Traditional Chinese Medicine/China
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