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Correlation of OX40 ligand on B cells with serum total IgE and IL-4 levels by CD4+ T cells in allergic rhinitis
Fouladi, S; Masjedi, M; Hakemi, MG; Ghasemi, R; Eskandari, N.
Afiliação
  • Fouladi, S; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Masjedi, M; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Hakemi, MG; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Ghasemi, R; Isfahan University of Medical Sciences. Faculty of Medicine. Department of Immunology. Isfahan. Iran
  • Eskandari, N; pplied Physiology Research Center
Allergol. immunopatol ; 47(3): 234-240, mayo-jun. 2019. graf, tab
Artigo em Inglês | IBECS | ID: ibc-186483
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Introduction and

objectives:

Allergic rhinitis (AR) is a classic Th2-mediated disease, with important contributions to the pathology of interleukins 4, 5, and 13. The co-stimulatory molecule of OX40 and its ligand interaction participate in the immune response by regulation of Th1/Th2 cells balance. Considering the paucity of information on the relation between OX40 ligand (OX40L) and AR, this study aimed to examine its expression on B lymphocytes. Patients and

methods:

This case-control study consisted of 20 AR patients and 20 healthy subjects. The serum level of total immunoglobulin E (IgE) was measured using the electro-chemiluminescence (ECL) technology. The percentage of B-lymphocytes expressing OX40L was assessed by flow cytometry. The amounts of IL-4 in CD4+ T cells culture supernatant was also measured by the enzyme-linked immunosorbent assay (ELISA).

Results:

OX40L expression on B lymphocytes of patients was significantly higher than the control group (44.32 ± 19.21% vs. 2.79 ± 2.48% respectively, p < 0.001). In AR patients, OX40L expression correlated positively with the levels of serum total IgE and IL-4 produced by CD4+ T lymphocytes (p < 0.01 - p < 0.05) respectively.

Conclusions:

Collectively, the findings of this work suggest that there is a relationship between the OX40L expression level on B lymphocytes and allergic markers such as IgE and IL-4 in patients with allergic rhinitis
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Imunoglobulina E / Linfócitos B / Biomarcadores / Interleucina-4 / Células Th2 / Ligante OX40 / Rinite Alérgica Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Isfahan University of Medical Sciences/Iran / pplied Physiology Research Center/Iran
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Imunoglobulina E / Linfócitos B / Biomarcadores / Interleucina-4 / Células Th2 / Ligante OX40 / Rinite Alérgica Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Inglês Revista: Allergol. immunopatol Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Isfahan University of Medical Sciences/Iran / pplied Physiology Research Center/Iran
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