What do we know about cancer immunotherapy? Long-term survival and immune-related adverse events
Allergol. immunopatol
; 47(3): 303-308, mayo-jun. 2019. tab
Artigo
em Inglês
| IBECS
| ID: ibc-186494
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Immunotherapy delivered a new therapeutic option to the oncologist Ipilimumab (anti-CTLA-4), Nivolumab and Pembrolizumab (anti-PD1), and Atezolizumab (anti-PD-L1) increase overall survival and show a better safety profile compared to chemotherapy in patients with metastatic melanoma, lung, renal cancer among others. But all that glitters is not gold and there is an increasing number of reports of adverse effects while using immune-checkpoint inhibitors. While chemotherapy could weaken the immune system, this novel immunotherapy could hyper-activate it, resulting in a unique and distinct spectrum of adverse events, called immune-related adverse events (IRAEs). IRAEs, ranging from mild to potentially life-threatening events, can involve many systems, and their management is radically different from that of cytotoxic drugs immunosuppressive treatments, such as corticoids, infliximab or mycophenolate mofetil, usually result in complete reversibility, but failing to do so can lead to severe toxicity or even death. Patient selection is an indirect way to reduce adverse events minimizing the number of subjects exposed to this drugs unfortunately PDL-1, the actual predictive biomarker, would not allow clinicians select or exclude patients for treatment with checkpoint inhibitors
RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
/
Anticorpos Monoclonais Humanizados
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Ipilimumab
/
Nivolumabe
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Imunossupressores
/
Imunoterapia
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Anticorpos Monoclonais
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Neoplasias
Limite:
Humanos
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hospital Universitario Quirónsalud/Spain
/
Hospital Universitario la Paz/Spain