The signal transducer and activator of transcription 6 (STAT-6) mediates Th2 inflammation and tissue damage in a murine model of peanut-induced food allergy
Allergol. immunopatol
; 47(6): 535-543, nov.-dic. 2019. tab, graf, ilus
Artigo
em Inglês
| IBECS
| ID: ibc-186545
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Introduction:
Food allergies are inflammatory conditions mediated by Th2 and probably STAT-6 dependent immune responses. Objective anddesign:
Here we investigated the role of Signal Transducer and Activator of Transcription 6 (STAT-6) in development of inflammation in peanut allergy.Methods:
To induce food allergy, wild-type (WT) and mice deficient for STAT-6 (Stat6-/-) were sensitized with peanut proteins and challenged with peanut seeds.Results:
WT animals lost weight and refused the peanut diet, in contrast to Stat6-/- mice, which had a better maintenance of body weight and more regular seeds' consumption. The augmented peanut-specific IgG, IgG1 and IgE in the allergic WT was abolished in Stat6-/- animals that also presented increased IgG2a. There was an overall reduction in the gut mediators in the absence of STAT-6, including those related to inflammatory and Th2 responses, in contrast to a rising counter regulatory and Th1 reaction in Stat-6-/- mice. These animals had IFN-γ and IL-10 similar to WT after the four-week challenge. Most interestingly, Stat-6-/- mice had no intestinal damage, in contrast to WT animals, which had inflammatory infiltrate, tissue destruction, epithelial exulceration, edema, congestion and loss of villous architecture in the small gut segments.Conclusions:
STAT-6 plays an important role in the establishment of the Th2 inflammatory responses and intestinal damage in peanut allergyRESUMEN
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Espanha
Base de dados:
IBECS
Assunto principal:
Células Th2
/
Hipersensibilidade a Amendoim
/
Fator de Transcrição STAT6
Limite:
Animais
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2019
Tipo de documento:
Artigo
Instituição/País de afiliação:
Fluminense Federal University/Brazil
/
University of São Paulo/Brazil
/
University of São Paulo, Ribeirão Preto/Brazil