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Ceftobiprole: pharmacokinetics and PK/PD profile
Azanza Perea, José Ramón; Sádaba Díaz de Rada, Belén.
Afiliação
  • Azanza Perea, José Ramón; Clínica Universidad de Navarra (University of Navarra Clinic). Clinical Pharmacology Department. Pamplona. Spain
  • Sádaba Díaz de Rada, Belén; Clínica Universidad de Navarra (University of Navarra Clinic). Clinical Pharmacology Department. Pamplona. Spain
Rev. esp. quimioter ; 32(supl.3): 11-16, sept. 2019. tab
Artigo em Inglês | IBECS | ID: ibc-188973
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Ceftobiprole shows many similar pharmacokinetic properties to other cephalosporins, except for not being orally bioactive, and that it is administered by IV infusion as the prodrug ceftobiprole medocaril, which is subsequently hydrolyzed in the blood into the active molecule. Distribution focus in extracellular fluid and active antibiotic concentration has been proven in different corporal tissues using dosing regimen of 500 mg intravenous infusion over 2 h every 8 h. Ceftobiprole is eliminated exclusively into the urine, thus the reason why dose adjustment is required for patients with moderate or severe renal impairment, or increased creatinine clearance. However, there is no need for dose adjustments related with other comorbidities and patients' conditions such as age, body weight. Although considering distribution features, molecular weight and dose fraction, increase dosing regimen might be necessary in patients using renal replacement therapy. The half-life of ceftobiprole is more than 3 h, allowing to easily reach optimal PK/PD parameters with the infusion time of 2 h, using the usual dosing regimen
RESUMEN
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Assuntos
Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Cefalosporinas / Antibacterianos Limite: Humanos Idioma: Inglês Revista: Rev. esp. quimioter Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Clínica Universidad de Navarra (University of Navarra Clinic)/Spain
Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Cefalosporinas / Antibacterianos Limite: Humanos Idioma: Inglês Revista: Rev. esp. quimioter Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Clínica Universidad de Navarra (University of Navarra Clinic)/Spain
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