A surgical study about jejunum: the exclusion to nutrients flow. A novel strategical technique
Eur. j. anat
; 24(2): 135-140, mar. 2020. graf
Artigo
em Inglês
| IBECS
| ID: ibc-191241
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The bariatric surgery techniques applied in patients with obesity have reported a great ability to improve Type 2 Diabetes mellitus (T2DM). Some published data report an increasing betacell mass in some surgical processes. This mechanism was specially seen in the bariatric surgeries which affect the length of the small bowel. The intrinsic mechanism that links both phenomena seemed to be related to the enterohormonal secretion pattern. Many enteral hormones have been invoked as the effector of these mechanisms. Previous reports focused on the medial portion of jejunum, as the precise place in which some particular enterohormones determine the homeostatic glycemic improvement. Goto-Kakizaki diabetic male rats underwent surgery to exclude the 50% medial jejunum from the normal nutrients flow. This medial portion of jejunum was not resected, but anastomosed by both extremes to the abdominal wall, and a stoma was performed. This surgery wasnamed as Medial Jejunal Exclusion (MJE). We studied the functional parameters in a three-month survival period. In this sense basal glycaemia, weight increase and food intake were not modified between the surgical and control groups. The study presented a mortality of the 24%. This model was designed for the late study of serum and enterohormones release in this jejunal portion, excluded of nutrients flow. We report a new surgical technique, which appears to balance the homeostatic processes in order to maintain the survival of diabetic rats. Thus, this mechanism could be in the basis of T2DM improvement, and this novel surgical model will help study this precise portion of jejunum
RESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Diabetes Mellitus Experimental
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Diabetes Mellitus Tipo 2
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Cirurgia Bariátrica
/
Jejuno
Limite:
Animais
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Cadiz Researcher Support Association/Spain
/
Ceuta Hospital/Spain
/
Research Biomedical Institute of Cadiz (INIBICA)/Spain
/
University of Cádiz/Spain