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Peri-implant peripheral giant cell lesions: report of 13 new cases and comparative histological and immunohistochemical analysis with peripheral and central giant cell lesions
Morais, Thayná Melo de Lima; Dantas Soares, Ciro; Aguirre Urizar, José Manuel; Alberdi-Navarro, Javier; Paes de Almeida, Oslei; Pires, Fábio Ramôa.
Afiliação
  • Morais, Thayná Melo de Lima; University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Brazil
  • Dantas Soares, Ciro; University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Brazil
  • Aguirre Urizar, José Manuel; University of the Basque Country (UPV/EHU). Department of Stomatology II. Leoia. Spain
  • Alberdi-Navarro, Javier; University of the Basque Country (UPV/EHU). Department of Stomatology II. Leoia. Spain
  • Paes de Almeida, Oslei; University of Campinas. Piracicaba Dental School. Department of Oral Diagnosis. Brazil
  • Pires, Fábio Ramôa; State University of Rio de Janeiro. School of Dentistry. Brazil
Med. oral patol. oral cir. bucal (Internet) ; 24(6): e739-e745, nov. 2019. tab, ilus, graf
Artigo em Inglês | IBECS | ID: ibc-192233
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

BACKGROUND:

Few cases or periimplant peripheral giant cell lesions (PGCL) have been reported in the literature. The aim of this study was to report 13 new cases of peri-implant PGCL and compare the expression of smooth muscle actin, Bcl-2 protein, GLUT-1, CD68, osteoprotegerin, receptor activator of nuclear factor kappa-B, Ki-67 and CD34 in these cases with PGCL and central giant cell lesions (CGCL). MATERIAL AND

METHODS:

Clinical data were retrieved from the laboratory records and histological analysis was performed using HE-stained slides. Immunohistochemical reactions for the above mentioned antibodies were performed and digitally scored.

RESULTS:

Peri-implant PGCL mostly affected the posterior mandible of adult females. CD68 and Bcl-2 expressions were higher in conventional PGCL and CGCL than in peri-implant PGCL (p = 0.033 for CD68 and p < 0.0001 for Bcl-2). Microvessel density was higher in conventional peripheral than in central and peri-implant PGCL (p = 0.002). Proliferative index of the mononuclear cells showed no statistically significant differences comparing the three groups but it was higher in peri-implant PGCL.

CONCLUSIONS:

The current study demonstrated that peri-implant PGCL is more common in the posterior mandible of adult females. There were some differences in microvessel density, proliferative activity and expression of CD68 and Bcl-2 among conventional PGCL, peri-implant and CGCL. Further studies are encouraged to better understand these early

findings:

RESUMEN
No disponible
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Granuloma de Células Gigantes / Implantação Dentária / Doenças da Gengiva Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: State University of Rio de Janeiro/Brazil / University of Campinas/Brazil / EHU)+Spain

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Granuloma de Células Gigantes / Implantação Dentária / Doenças da Gengiva Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: State University of Rio de Janeiro/Brazil / University of Campinas/Brazil / EHU)+Spain
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