Your browser doesn't support javascript.
loading
Los niveles de interleucina-5 disminuyen en plasma de pacientes con enfermedad coronaria e inhiben la diferenciación in vitro de Th1 y Th17 / Interleukin-5 levels are decreased in the plasma of coronary artery disease patients and inhibit Th1 and Th17 differentiation in vitro
Ye, Di; Wang, Zhen; Ye, Jing; Wang, Menglong; Liu, Jianfang; Xu, Yao; Jiang, Huimin; Chen, Jiangbin; Wan, Jun.
Afiliação
  • Ye, Di; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Wang, Zhen; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Ye, Jing; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Wang, Menglong; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Liu, Jianfang; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Xu, Yao; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Jiang, Huimin; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Chen, Jiangbin; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
  • Wan, Jun; Renmin Hospital of Wuhan University. Department of Cardiology. Wuhan. China
Rev. esp. cardiol. (Ed. impr.) ; 73(5): 393-402, mayo 2020. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-194547
Biblioteca responsável: ES1.1
Localização: BNCS
RESUMEN
INTRODUCCIÓN Y

OBJETIVOS:

La interleucina 5 (IL-5) es una citocina antiinflamatoria que se ha involucrado en las enfermedades cardiovasculares, incluidos los aneurismas aórticos y la insuficiencia cardiaca. El objetivo de este estudio es investigar el papel de la IL-5 en la enfermedad coronaria (EC) y sus posibles mecanismos.

MÉTODOS:

Se analizó la expresión de la IL-5 en muestras de arterias coronarias humanas de 17 pacientes con EC y donantes fallecidos. Además, se determinaron las concentraciones plasmáticas de IL-5, IL-17 e interferón gamma en pacientes con EC usando kits ELISA con muestras de pacientes con dolor torácico (sin EC) como controles. Se separaron las células murinas CD4+T helper (Th), y el efecto de la IL-5 en la diferenciación de Th1, célula T reguladora y Th17 y la cantidad de ARNm de sus citocinas características se determinaron mediante citometría de flujo y reacción en cadena de la polimerasa tras transcripción inversa respectivamente.

RESULTADOS:

La IL-5 disminuyó significativamente en las placas coronarias de los pacientes con EC comparados con el grupo de donantes fallecidos, y la IL-5 derivó fundamentalmente de los macrófagos de las placas de las arterias coronarias. Además, comparados con el grupo sin EC, las concentraciones plasmáticas de IL-5 en el grupo de EC fueron significativamente menores, y la secuencia de mayor a menor fue angina estable, angina inestable e infarto de miocardio. El análisis de regresión linear binaria mostró que la IL-5 se correlacionó independientemente con la aparición de la EC. Además, el tratamiento con IL-5 recombinante de ratón disminuyó los valores de Th1 y Th17 y la expresión del ARNm de sus citocinas características en lipoproteínas oxidadas de baja densidad tratadas con CD4+Th.

CONCLUSIONES:

Los valores de IL-5 disminuyeron en los pacientes con EC e inhiben la diferenciación in vitro de Th1 y Th17 inducida por lipoproteínas oxidadas de baja densidad
ABSTRACT
INTRODUCTION AND

OBJECTIVES:

Interleukin (IL)-5 is an anti-inflammatory cytokine that has been demonstrated to be involved in cardiovascular diseases, including aortic aneurysm and heart failure. This study aimed to investigate the involvement of IL-5 in coronary artery disease (CAD) and the possible mechanisms.

METHODS:

We analyzed IL-5 expression in human coronary artery specimens collected from CAD patients and deceased donors. Plasma IL-5, IL-17, and interferon-γ levels in CAD patients were detected using ELISA kits, with samples from chest pain patients (non-CAD) as controls. Mouse CD4+T helper (Th) cells were separated, and the effect of IL-5 on Th1, regulatory T cell and Th17 differentiation and mRNA levels of their characteristic cytokines were detected using flow cytometry and reverse transcription-quantitative polymerase chain reaction, respectively.

RESULTS:

IL-5 was significantly decreased in the coronary plaque of CAD patients compared with the deceased donors group, and IL-5 was mainly derived from macrophages in the coronary artery plaque. Compared with the non-CAD group, plasma IL-5 levels in the CAD groups were significantly lower, and the sequence from high to low was stable angina pectoris, unstable angina pectoris, and acute myocardial infarction. Binary linear regression analysis showed that IL-5 was independently correlated with the occurrence of CAD. Recombinant mouse IL-5 treatment decreased Th1 and Th17 levels and mRNA expression of their characteristic cytokines in oxidized low-density lipoprotein-treated CD4+Th cells.

CONCLUSION:

IL-5 levels were decreased in CAD patients and inhibited oxidized low-density lipoprotein Th1 and Th17 differentiation in vitro
Assuntos
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Interleucina-5 / Células Th1 / Doença das Coronárias / Células Th17 Limite: Idoso / Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. esp. cardiol. (Ed. impr.) Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Renmin Hospital of Wuhan University/China
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Interleucina-5 / Células Th1 / Doença das Coronárias / Células Th17 Limite: Idoso / Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. esp. cardiol. (Ed. impr.) Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Renmin Hospital of Wuhan University/China
...