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Effectiveness of rectal indomethacin in the prevention of acute pancreatitis after endoscopic retrograde cholangiopancreatography in unselected patients
Lindo Ricce, Mayra; Rodríguez López-Salazar, Teresa; Mendoza Jiménez-Ridruejo, Jorge; Moreno Monteagudo, Jose Andrés; Santander Vaquero, Cecilio.
Afiliação
  • Lindo Ricce, Mayra; Hospital Universitario de La Princesa. Department of Gastroenterology. Madrid. Spain
  • Rodríguez López-Salazar, Teresa; Hospital Universitario de La Princesa. Department of Gastroenterology. Madrid. Spain
  • Mendoza Jiménez-Ridruejo, Jorge; Hospital Universitario de La Princesa. Department of Gastroenterology. Madrid. Spain
  • Moreno Monteagudo, Jose Andrés; Hospital Universitario de La Princesa. Department of Gastroenterology. Madrid. Spain
  • Santander Vaquero, Cecilio; Hospital Universitario de La Princesa. Department of Gastroenterology. Madrid. Spain
Rev. esp. enferm. dig ; 112(3): 183-188, mar. 2020. tab, graf
Artigo em Inglês | IBECS | ID: ibc-195792
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND AND

AIMS:

several studies have shown that rectal indomethacin decreases the risk of acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). However, in recent studies, its effectiveness is being questioned, especially in average risk patients. Our principal aim was to evaluate the efficacy of rectal indomethacin prophylaxis in the development of post-ERCP pancreatitis (PEP).

METHODS:

a retrospective cohort study was conducted at a third-level university hospital. Data was collected from every patients who underwent ERCP between January 2014 and June 2016. After February 2015, all patients received 100 mg of rectal indomethacin prior to ERCP. We analyzed groups, with indomethacin and without indomethacin, in unselected patients.

RESULTS:

a total of 524 patients were analyzed, with a mean age of 71.1 ± 17.0 (standard deviation [SD]) years. Of the total number of patients, 393 (75%) had an average risk; 277 received rectal indomethacin prior to ERCP, while 247 did not. In the group with indomethacin, 12 patients developed PEP (4.33%) versus ten in the indomethacin-free group (4.04%) (OR 1.33; 95% confidence interval [CI], 0.52-3.40; p = 0.56). Severe-moderate PEP developed in seven patients (2.52%) in the indomethacin group and in two patients (0.81%) in the indomethacin-free group (p = 0.24). Previous sphincterotomy was a protective factor (OR 0.02; 95% CI, 0.02-0.2; p = 0.001) and age < 45 years was a risk factor (OR 3.43; 95% CI, 1.14-10.32; p = 0.03).

CONCLUSIONS:

rectal indomethacin does not appear to decrease the risk of developing PEP in unselected patients
RESUMEN
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Pancreatite / Anti-Inflamatórios não Esteroides / Indometacina / Colangiopancreatografia Retrógrada Endoscópica Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. esp. enferm. dig Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitario de La Princesa/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Pancreatite / Anti-Inflamatórios não Esteroides / Indometacina / Colangiopancreatografia Retrógrada Endoscópica Limite: Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Rev. esp. enferm. dig Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: Hospital Universitario de La Princesa/Spain
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