The impact of head and neck radiotherapy on the dentine-enamel junction: a systematic review
Med. oral patol. oral cir. bucal (Internet)
; 25(1): e96-e105, ene. 2020. graf
Artigo
em Inglês
| IBECS
| ID: ibc-196201
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
BACKGROUND:
Radiotherapy is widely used in contemporary head and neck cancer treatment protocols. The abil-ity of head and neck radiotherapy (HNRT) to cause direct radiogenic destruction to the teeth is one of the most controversial topics in the field of oral oncology. Therefore, this systematic review aimed to investigate ionising radiation as an independent factor for physical and chemical changes on the dentine-enamel junction (DEJ), a piv-otal dental topography for the onset and progression of radiation-related caries (RRC) and enamel delamination. MATERIAL ANDMETHODS:
Systematic searches were conducted on three databases Scopus, MEDLINE (Via PubMed) and Embase (Elsevier). Laboratory studies evaluating the effects of simulated or in vivo HNRT on the DEJ were included. The GRADE tool adapted for in vitro studies was used to assess the methodological quality.RESULTS:
Of the 154 initially selected studies, eight met the inclusion criteria, from which five studies were graded as high quality of evidence, two studies were graded as moderate quality and one as low quality. Two studies did not demonstrate DEJ alterations following HNRT while the other six articles described several organic and inorganic changes in the DEJ of irradiated teeth samples. These radiogenic events were mostly detected through micro and na-noindentation, Raman micro-spectroscopy, confocal microscopy, Western blotting and optical coherence tomography.CONCLUSIONS:
HNRT may have a negative impact on the physical and chemical aspects of the DEJ, predisposing can-cer patients to RRC and enamel delaminationRESUMEN
No disponible
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Lesões por Radiação
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Cárie Dentária
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Esmalte Dentário
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Dentina
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Neoplasias de Cabeça e Pescoço
Limite:
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad de Valparaíso/Chile
/
Universidade de São Paulo/Brazil
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University of Campinas (UNI-CAMP)/Brazil
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University of Campinas (UNICAMP) Piracicaba/Brazil