The relationship between glomerular filtration rate, and metabolic and inflammatory parameters in obese and non-obese patients with polycystic ovary syndrome
Clín. investig. arterioscler. (Ed. impr.)
; 32(6): 256-262, nov.-dic. 2020. tab
Artigo
em Inglês
| IBECS
| ID: ibc-197452
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
AIM:
To investigate the relationship between glomerular filtration rates (GFR), and homeostasis model assesment of insulin resistance (HOMA-IR), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) in patients with polycystic ovary syndrome (PCOS). MATERIAL ANDMETHODS:
Thirty-one overweight and obese PCOS patients with body mass index (BMI)≥25kg/m2 and 25 non-obese PCOS patients with BMI<25kg/m2 were included into patients' group, while 23 overweight and obese, and 25 non-obese age-and BMI-matched healthy individuals (aged between 18 and 40 years), were enrolled as controls. Levels of serum creatinine, glucose, insulin, CRP, and complete blood count were measured. eGFR, HOMA-IR and NLR were also calculated.RESULTS:
In PCOS group, HOMA-IR (p = 0.001), CRP (p = 0.025) and waist hip ratio (WHR) (p = 0.011) were higher than controls. In obese PCOS sub-group, HOMA-IR (p = 0.004) and WHR (p = 0.002) were higher than obese controls. In non-obese PCOS sub-group, HOMA-IR (p = 0.001) were higher than non-obese controls. In obese PCOS sub-group; HOMA-IR (p = 0.001) and CRP (p = 0.001) levels were significantly higher than non-obese PCOS sub-group. In terms of other parameters, no significant difference was found between the groups. The analysis showed a negative correlation between GFR, and BMI and HOMA-IR in PCOS group, between GFR, WHR and insulin levels in obese PCOS sub-group, and between BMI, and HOMA-IR and NLR in non-obese PCOS sub-group.CONCLUSION:
Although HOMA-IR and CRP were higher in PCOS group, there was no difference in NLR and GFR levels between those with PCOS and controlsRESUMEN
OBJETIVO:
investigar la relación entre las tasas de filtración glomerular (TFG) y la evaluación del modelo de homeostasis de la resistencia a la insulina (HOMA-IR), la proteína C-reactiva (PCR) y la relación de neutrófilos a linfocitos (NLR) en pacientes con síndrome de ovario poliquístico (PCOS). MATERIAL YMÉTODOS:
Treinta y un pacientes con PCOS con sobrepeso y obesidad con índice de masa corporal(IMC) ≥25 kg/m 2 y 25 pacientes con PCOS no obesos con IMC <25 kg/m 2 constituyeron el grupo de pacientes, mientras que 23 con sobrepeso y obesidad, y Se inscribieron como controles 25 sujetos sanos no obesos, todos con edad e IMC(edad entre 18 y 40 años). Se midieron los niveles séricos de creatinina, glucosa, insulina y PCR, y se evaluó el recuento sanguíneo completo; Se calcularon eGFR, HOMA-IR y NLR.RESULTADOS:
en el grupo PCOS, HOMA-IR (p = 0.001), CRP (p = 0.025) y la relación cintura-cadera(WHR) (p = 0.011) fueron más altos que los controles. En el subgrupo de PCOS obesos, HOMA-IR (p = 0.004) y WHR (p = 0.002) fueron más altos que los controles obesos. En el subgrupo PCOS no obeso, HOMA-IR (p = 0.001) fue mayor que los controles no obesos. En el subgrupo de PCOS obesos; Los niveles de HOMA-IR (p = 0.001) y CRP (p = 0.001) fueron significativamente más altos que los del subgrupo PCOS no obeso. En cuanto a otros parámetros, no se encontraron diferencias significativas entre los grupos.CONCLUSIÓN:
Aunque los niveles de HOMA-IR y CRP se encontraron más altos en el grupo PCOS, no hubo diferencias en los niveles de NLR y GFR entre aquellos con PCOS y controles
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Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Síndrome do Ovário Policístico
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Resistência à Insulina
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Sobrepeso
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Taxa de Filtração Glomerular
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Obesidade
Limite:
Adolescente
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Adulto
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Feminino
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Humanos
Idioma:
Inglês
Revista:
Clín. investig. arterioscler. (Ed. impr.)
Ano de publicação:
2020
Tipo de documento:
Artigo
Instituição/País de afiliação:
Medical School of Usak University/Turkey
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Meram Medical School of Necmettin Erbakan University/Turkey
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University of Health Sciences/Turkey