Emerging roles of JMJD3 in cancer
Clin. transl. oncol. (Print)
; 24(7): 1238-1249, julio 2022.
Artigo
em Inglês
| IBECS
| ID: ibc-203825
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Histone lysine methylation plays a key role in gene activation and repression. The trimethylation of histone H3 on lysine-27 (H3K27me3) is a critical epigenetic event that is controlled by Jumonji domain-containing protein-3 (JMJD3). JMJD3 is a histone demethylase that specifically removes methyl groups. Previous studies have suggested that JMJD3 has a dual role in cancer cells. JMJD3 stimulates the expression of proliferative-related genes and increases tumor cell growth, propagation, and migration in various cancers, including neural, prostate, ovary, skin, esophagus, leukemia, hepatic, head and neck, renal, lymphoma, and lung. In contrast, JMJD3 can suppress the propagation of tumor cells, and enhance their apoptosis in colorectal, breast, and pancreatic cancers. In this review, we summarized the recent advances of JMJD3 function in cancer cells.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Histonas
/
Apoptose
/
Histona Desmetilases
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Ahvaz Jundishapur University of Medical Sciences/Iran
/
Arak University of Medical Sciences/Iran
/
Ardabil University of Medical Sciences/Iran
/
Faculty of Nursing and Midwifery/Iran
/
Isfahan University of Medical Sciences/Iran
/
Islamic Azad University/Iran
/
Nemazi Hospital/Iran
/
University of Barcelona (UB)/Spain