A novel immune-related RNA-binding proteins signature to predict survival and therapeutic responses in prostate cancer
Clin. transl. oncol. (Print)
; 24(7): 1381-1394, julio 2022. tab
Artigo
em Inglês
| IBECS
| ID: ibc-203837
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
BackgroundThe present study aims to identify immune-related RBPs signature to predict prognosis and therapy response in prostate cancer.MethodsDifferentially expressed RBPs were compared and visualized using R packages. Immune-related RBPs were selected by Pearson correlation analysis. The prognostic immune-related RBPs were identified using the KaplanMeier method and LASSO regression. A multivariable Cox regression model was used to construct immune-related RBPs signature.ResultsWe constructed a prognostic predictive risk model of prostate cancer containing ten immune-related RBP genes. We found that high-risk prostate cancer patients presented poorer prognosis, higher tumor immune cell infiltration, higher rates of genomic alterations, and were more sensitive to targeted and immunotherapy than the low-risk group.ConclusionsThe immune-related RBPs signature is an independent prognostic marker that could help screen patients with advanced prostate cancer who are better suited for targeted and immunotherapy.
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Próstata
/
Modelos de Riscos Proporcionais
/
Imunoterapia
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
The First Affiliated Hospital of Anhui Medical University/China