Anticancer Properties of Caulerpa racemosa: A Review Study
Nutr. clín. diet. hosp
; 42(3): 110-121, Ago 2022. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-207355
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
Introduction:
Cancer is the leading cause of death in theworld, with approximately 10 million deaths expected by2020. Several approaches are used in cancer management.However, the cost is one of the main obstacles in cancer therapy as well as side effects in sufferers. Caulerpa racemosa is a type of seaweed that is naturally abundant in theIndonesian sea. Recently, there has been much research onthe anticancer effects of Caulerpa sp. This study aims to findthe potency of Sea grapes extract (Caulerpa racemosa) in thetreatment of cancer and its mechanisms.Method:
A review of the literature was constructed on thepotential of the C. racemosa extract with the PICOS criteriaand the data were extracted from PUBMED, ScienceDirectand SpringerLink. The search method was using a booleanoperator with the main keywords Caulerpa racemosa, cancer, and Management.Results:
The main results were 8 articles including in vitroand in vivo experimental studies based on inclusion criteria.Several studies (n=8) revealed the potency of C. racemosaextract as an anticancer agent through various activities, suchas antiproliferative, apoptotic, antioxidant, cytotoxic activity,and inhibition of tumor progression genes, DNMT, and upregulation of proapoptotic genes, including BAX, P53, Caspase-3, Caspase-8, and Caspase-9.Discussion:
C. racemosa possesses several potent antioxidant substances, along with gene regulation activities and in hibition of cell line proliferation. Seaweeds has been usedwidely as functional food and showed minimal or no toxicitiesagainst human. With all these benefits, C. racemosa has thepotential to be commercialized as a promising diet for cancerpatients.Conclusion:
Sea grapes extract (C. racemosa) has goodpotential as an anticancer agent through antiproliferationmechanisms, induction of apoptosis, cytotoxic and antioxidantactivity.(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Alga Marinha
/
Suplementos Nutricionais
/
Citotoxicidade Imunológica
/
Caulerpa
/
Alimento Funcional
/
Fator Apoptótico 1 Ativador de Proteases
/
Compostos Fitoquímicos
/
Neoplasias
/
Antineoplásicos
/
Antineoplásicos Fitogênicos
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Nutr. clín. diet. hosp
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Brawijaya University/Indonesia
/
State Islamic University of Sunan Kalijaga (UIN Sunan Kalijaga Yogyakarta)/Indonesia