Essential role of aerobic glycolysis in epithelial-to-mesenchymal transition during carcinogenesis
Clin. transl. oncol. (Print)
; 24(10): 18441855, octubre 2022.
Artigo
em Espanhol
| IBECS
| ID: ibc-207941
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
RESUMEN
Epithelial-to-mesenchymal transition (EMT) confers the most lethal characteristics to cancer cells i.e., metastasis and resistance to chemo-and-radio-therapy, and therefore exhibit an appealing target in the field of oncology. Research in the past decade has demonstrated the crucial role of aerobic glycolysis in EMT, which is generally credited as the glucose metabolism for the creation of biomass such as fatty acids, amino acids, and nucleotides thereby providing building blocks for limitless proliferation. In the present review, apart from discussing EMTs evident role in the metastatic process and cancer stemness, we also talked about the vital role of glycolytic enzymes viz. GLUTs, HKs, PGI, PFK-1, aldolase, enolase, PK, LDHA, etc. in the induction of the EMT process in cancerous cells. (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Células-Tronco Neoplásicas
/
Transição Epitelial-Mesenquimal
/
Carcinogênese
/
Glicólise
Limite:
Humanos
Idioma:
Espanhol
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
India Institute of Medical Sciences/India