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Bone regeneration at extraction sockets filled with leukocyte-platelet-richfibrin: An experimental pre-clinical study
Park, Gene; Jalkh, Ernesto B Benalcázar; Boczar, Daniel; Bergamo, Edmara TP; Kim, Heoijin; Kurgansky, Gregory; Torroni, Andrea; Gil, Luiz F; Bonfante, Estevam A; Coelho, Paulo G; Witek, Lukasz.
Afiliação
  • Park, Gene; New York University. College of Dentistry. Department of Biomaterials. New York. USA
  • Jalkh, Ernesto B Benalcázar; University of Sao Paulo. Bauru School of Dentistry. Bauru. Brazil
  • Boczar, Daniel; New York University. College of Dentistry. New York. USA
  • Bergamo, Edmara TP; University of Sao Paulo. Bauru School of Dentistry. Bauru. Brazil
  • Kim, Heoijin; New York University. College of Dentistry. New York. USA
  • Kurgansky, Gregory; New York University. College of Dentistry. New York. USA
  • Torroni, Andrea; New York University. Langone Medical Center. New York. USA
  • Gil, Luiz F; Federal University of Santa Catarina. Department of Morphological Sciences. Brazil
  • Bonfante, Estevam A; University of Sao Paulo. Bauru School of Dentistry. Bauru. Brazil
  • Coelho, Paulo G; University of Miami. Miller School of Medicine. Miami. USA
  • Witek, Lukasz; New York University. College of Dentistry. New York. USA
Med. oral patol. oral cir. bucal (Internet) ; 27(5): e468-e475, September 01, 2022. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-209814
Biblioteca responsável: ES1.1
Localização: ES15.1 - BNCS
ABSTRACT

Background:

We aimed to histomorphometrically evaluate the effects of Leucocyte-Platelet-Rich Fibrin (L-PRF),with and without the combination of a bone grafting material, for alveolar ridge preservation using an in vivocanine model.Material and

Methods:

Seven dogs (Female Beagles, ~18-month-old) were acquired for the study. L-PRF wasprepared from each individual animal by drawing venous blood and spinning them through a centrifuge at 408RCF-clot (IntrasSpin, Intra-Lock, Boca Raton, FL). L-PRF membranes were obtained from XPression fabrication kit (Biohorizons Implant Systems, Inc., AL, USA). A split mouth approach was adopted with the first molarmesial and distal socket defects treated in an interpolated fashion of the following study groups 1) Empty socket (negative control); 2) OSS filled defect 3) L-PRF membrane; and 4) Mix of Bio-Oss® with L-PRF. After six weeks,samples were harvested, histologically processed, and evaluated for bone area fraction occupancy (BAFO), vertical/horizontal ridge dimensions (VRD and HRD, respectively), and area of coronal soft tissue infiltration.

Results:

BAFO was statistically lower for the control group in comparison to all treatment groups. Defects treatedwith Bio-Oss® were not statistically different then defects treated solely with L-PRF. Collapsed across all groups,L-PRF exhibited higher degrees of BAFO than groups without L-PRF. Defects filled with Bio-Oss® and Bio-Oss®with L-PRF demonstrated greater maintenance of VRD relative to the control group. Collapsed across all groups,Bio-Oss® maintained the VRD and resulted in less area of coronal soft tissue infiltration compared to the emptydefect. Soft tissue infiltration observed at the coronal area was not statistically different among defects filled withL-PRF, Bio-Oss®, and Bio-Oss® with L-PRF.

Conclusions:

Inclusion of L-PRF to particulate xenograft did not promote additional bone heading at 6 weeks invivo. ... (AU)
Assuntos


Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Extração Dentária / Regeneração Óssea / Alvéolo Dental / Processo Alveolar / Fibrina Rica em Plaquetas / Leucócitos / Dente Molar Limite: Animais Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2022 Tipo de documento: Artigo Instituição/País de afiliação: Federal University of Santa Catarina/Brazil / New York University/USA / University of Miami/USA / University of Sao Paulo/Brazil

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Extração Dentária / Regeneração Óssea / Alvéolo Dental / Processo Alveolar / Fibrina Rica em Plaquetas / Leucócitos / Dente Molar Limite: Animais Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2022 Tipo de documento: Artigo Instituição/País de afiliação: Federal University of Santa Catarina/Brazil / New York University/USA / University of Miami/USA / University of Sao Paulo/Brazil
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