Resveratrol inhibits TGF-B1-induced EMT in gastric cancer cells through Hippo-YAP signaling pathway
Clin. transl. oncol. (Print)
; 24(11): 2210-2221, noviembre 2022.
Artigo
em Inglês
| IBECS
| ID: ibc-210149
Biblioteca responsável:
ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
To investigate the effects of resveratrol (RSVL) on epithelial-mesenchymal transition (EMT) and biological behaviors of gastric cancer cells.MethodsSGC-7901 cells were treated with RSVL, followed by TGF-β1 treatment for induction of EMT. Cell proliferation was tested by MTT assay, migration and invasion by Transwell and scratch assays, and Hippo-YAP signaling pathway activation by immunofluorescence. The RNA and protein expressions of E-cadherin, Vimentin, N-cadherin, and Snail were detected by qPCR and Western blot. A tumor model was constructed to examine the effect of RSVL on gastric tumor growth.ResultsRSVL inhibited the migration, invasion, and growth of gastric cancer cells in concentration- and time-dependent manners. RSVL inhibited TGF-β1-induced EMT of gastric cancer cells, which might relate to inactivation of the Hippo-YAP pathway. In the mouse tumor model, RSVL inhibited the EMT process by suppressing the Hippo-YAP pathway.ConclusionRSVL inhibited EMT of gastric cancer cells probably by weakening the Hippo-YAP signaling pathway. (AU)
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Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Vimentina
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Caderinas
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Movimento Celular
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Proteínas Serina-Treonina Quinases
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Linhagem Celular Tumoral
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Transição Epitelial-Mesenquimal
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Resveratrol
Limite:
Humanos
Idioma:
Inglês
Revista:
Clin. transl. oncol. (Print)
Ano de publicação:
2022
Tipo de documento:
Artigo
Instituição/País de afiliação:
Gaoxin Branch Of The First Affiliated Hospital Of Nanchang University/Peoples Republic of China
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The Second Affiliated Hospital of Nanchang Medical College/Peoples Republic of China