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Antiviral activity of nano-monocaprin against Phi6 as a surrogate for SARS-CoV-2 / Actividad antiviral de nano-monocaprina contra Phi6 como sustituto del SARS-CoV-2
Sorinolu, Adeola Julian; Mamun, M. Mustafa; Vadarevu, Hemapriyadarshini; Vivero-Escoto, Juan L; Vejerano, Eric P; Munir, Mariya.
Afiliação
  • Sorinolu, Adeola Julian; University of North Carolina at Charlotte. Department of Chemistry. Charlotte. USA
  • Mamun, M. Mustafa; University of North Carolina at Charlotte. Department of Chemistry. Charlotte. USA
  • Vadarevu, Hemapriyadarshini; University of North Carolina at Charlotte. Department of Chemistry. Charlotte. USA
  • Vivero-Escoto, Juan L; University of North Carolina at Charlotte. Department of Chemistry. Charlotte. USA
  • Vejerano, Eric P; University of North Carolina at Charlotte. Department of Chemistry. Charlotte. USA
  • Munir, Mariya; University of North Carolina at Charlotte. Department of Chemistry. Charlotte. USA
Int. microbiol ; 26(2): 379-387, May. 2023. ilus, graf
Artigo em Inglês | IBECS | ID: ibc-220229
Biblioteca responsável: ES1.1
Localização: ES15.1 - BNCS
ABSTRACT
The COVID-19 pandemic involving SARS-CoV-2 has raised interest in using antimicrobial lipid formulations to inhibit viral entry into their host cells or to inactivate them. Lipids are a part of the innate defense mechanism against pathogens. Here, we evaluated the use of nano-monocaprin (NMC) in inhibiting enveloped (phi6) and unenveloped (MS2) bacteriophages. NMC was prepared using the sonochemistry technique. Size and morphology analysis revealed the formation of ~ 8.4 ± 0.2-nm NMC as measured by dynamic light scattering. We compared the antiviral activity of NMC with molecular monocaprin (MMC) at 0.5 mM and 2 mM concentrations against phi6, which we used as a surrogate for SARS-CoV-2. The synthesized NMC exhibited 50% higher antiviral activity against phi6 than MMC at pH 7 using plaque assay. NMC inactivated phi6 stronger at pH 4 than at pH 7. To determine if NMC is toxic to mammalian cells, we used MTS assay to assess its IC50 for HPDE and HeLa cell lines, which were ~ 203 and 221 µM, respectively. NMC may be used for prophylactic application either as a drop or spray since many viruses enter the human body through the mucosal lining of the nose, eyes, and lungs.(AU)
Assuntos


Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Bacteriófagos / Infecções por Coronavirus / Coronavírus Relacionado à Síndrome Respiratória Aguda Grave / Pandemias / Lipídeos / Anti-Infecciosos Limite: Humanos Idioma: Inglês Revista: Int. microbiol Ano de publicação: 2023 Tipo de documento: Artigo Instituição/País de afiliação: University of North Carolina at Charlotte/USA

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Bacteriófagos / Infecções por Coronavirus / Coronavírus Relacionado à Síndrome Respiratória Aguda Grave / Pandemias / Lipídeos / Anti-Infecciosos Limite: Humanos Idioma: Inglês Revista: Int. microbiol Ano de publicação: 2023 Tipo de documento: Artigo Instituição/País de afiliação: University of North Carolina at Charlotte/USA
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