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Aspectos de seguridad del ácido linoleico conjugado, con especial relevancia en la infancia / Safety features of conjugated linoleico acid, with special importante in childhood
Anadón Navarro, A.
Afiliação
  • Anadón Navarro, A; Universidad Complutense de Madrid. Facultad de Veterinaria. Madrid. España
Rev. esp. pediatr. (Ed. impr.) ; 64(1): 74-88, ene.-feb. 2008. tab
Artigo em Espanhol | IBECS | ID: ibc-59808
Biblioteca responsável: ES1.1
Localização: BNCS
RESUMEN
En este trabajo se describen estudios preclínicos y clínicos del ácido linoleico conjugado (CLA). En 2 ensayos de mutagénesis el CLA demuestra efectos negativos. En un estudio de toxicidad subcrónica en ratas alimentadas con CLA (1,5 ó 15%) se identificó un NOAEL de 2.433 y 2.728 mg/kg pc/día para machos y hembras. Dos estudios de toxicidad crónica en ratas alimentadas con CLA (1 y 1.5%) no presentaron signos de toxicidad. Un estudio de teratogénesis y toxicidad post-natal en ratas alimentadas con CLA (0,25 y 0,5%) no evidenció efectos adversos. Estudio clínico con CLA a dosis de 3,4 g/día durante 2 años en sujetos adultos fue seguro y bien tolerado. Otros estudios en que se administró CLA a dosis de 6g/día durante 12 meses y 3g/día durante 12 semanas demostraron ser bien tolerados. Un meta-análisis efectuado concluyó que el CLA a dosis de 3,2 g/día produce una modesta pérdida de la masa de grasa corporal (MGC). Estudios clínicos en niños y adolescentes obesos a los que se administró CLA a una dosis de 3g/día durante 6 a 12 meses no produjo alteraciones en los patrones habituales de crecimiento. En otro estudio realizado en la edad pediátrica y adulta en obesos que recibieron durante 16 semanas dos envases de 100 g de yogur suplementado con CLA se observó en base a los parámetros de seguridad evaluados y la clínica de los pacientes que este compuesto era seguro. Se presenta, por último, un Post Launch Monitoring de productos Naturlínea conteniendo CLA como Tonalin y conclusiones sobre la seguridad del CLA (AU)
ABSTRACT
This paper presents pre-clinical y clinical studies of conjugated linoleic acid (CLA). Two mutagenicity studies have evidence CLA negative effects. A subchronic study in rats fed with CLA (1,5 or 15%) concluded a NOAEL of 2.433 and 2.728 mg/kg bw/day for male and female, respectively. Two chronic toxicity studies in rats fed with CLA (1 and 1,5%) no signs of toxicity were showed. A teratogenic and post-natal toxicity study in the rat fed with CLA (0.25% or 0.5%) did not evidence adverse effects. A clinical study with CLA at dose of 3.4 g/day for 2 years in obese adult subjects was safe and tolerated. In other studies in which CLA was administed at doses of 6g/day during 12 months and 3g/day for 12 weeds showed to be well tolerated. A meta-analysis of human studies in which CLA was provided as a dietary supplement concluded that CLA was provide as a dietary supplement concluded that CLA given at a dose of 3.2 g/day produced a modest loss in body fat. Obese children and adolescent clinical studies in which CLA was provided as a dietary supplement concluded that CLA given at a dose of 3.2 g/day produced a modest loss in body fat. Obese children and adolescent clinical studies in which CLA was administered at a dose of 3g/day for 6 to 12 months did not produce changes in usual pattern of growth. Other study performed with obese adolescents during 16 weeks receiving a daily amount of 200 g of yogurt supplemented with CLA was safe. Finally a “Post Launch Monitoring” of Naturlinea products containing CLA as Tonalin and general conclusions on safety of CLA were presented (AU)
Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Ácidos Linoleicos Conjugados / Obesidade Limite: Animais / Humanos Idioma: Espanhol Revista: Rev. esp. pediatr. (Ed. impr.) Ano de publicação: 2008 Tipo de documento: Artigo Instituição/País de afiliação: Universidad Complutense de Madrid/España
Buscar no Google
Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Ácidos Linoleicos Conjugados / Obesidade Limite: Animais / Humanos Idioma: Espanhol Revista: Rev. esp. pediatr. (Ed. impr.) Ano de publicação: 2008 Tipo de documento: Artigo Instituição/País de afiliação: Universidad Complutense de Madrid/España
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