ZAG, a lipid mobilizing adipokine, is downregulated in human obesity

ABSTRACT

The main goal of this study was to compare the expression of Zinc-á2-glycoprotein(ZAG), a recently described adipokine, in obese and lean subjects. ZAG expressionwas determined by Real-time PCR analysis in subcutaneous abdominal adiposetissue of eighteen young men, 9 lean (BMI=23.1±0.4 kg/m2) and 9 obese (34.7±1.2kg/m2) with a similar habitual dietary intake of fat and physical activity, which wereassessed by validated methods. Our data revealed that ZAG gene was downregulated(–70%; p<0.05) in subcutaneous adipose tissue of obese compared to lean subjects.Moreover, statistically significant positive correlations between ZAG gene expressionand serum adiponectin (r=0.89; p<0.01) and a negative correlation with the plasmalevels of leptin (r=–0.82; p<0.05) and waist circumference (r=–0.64; p<0.05) werefound in obese subjects. Our data suggest that this novel adipokine could play a rolein human susceptibility to obesity related disorders and that upregulation of ZAGcould be a promising therapeutic target for metabolic syndrome treatment (AU)

RESUMEN

No disponible