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Effects of gamma-hydroxybutyrate (liquid ecstasy) on the eye development of the chick embryo
Pascual-Morenilla, MT; Guirao-Piñeyro, M; Robles-Garzón, F; Roda-Moreno, JA; López-Soler, M; Arrebola-Nacle, F; Casanova-Llivina, JA; Roda-Murillo, O.
Afiliação
  • Pascual-Morenilla, MT; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • Guirao-Piñeyro, M; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • Robles-Garzón, F; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • Roda-Moreno, JA; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • López-Soler, M; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • Arrebola-Nacle, F; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • Casanova-Llivina, JA; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
  • Roda-Murillo, O; University of Granada. Neurosciences Institute. Department of Human Anatomy and Embryology. Granada. Spain
Eur. j. anat ; 12(3): 139-143, dic. 2008. tab
Artigo em Inglês | IBECS | ID: ibc-61833
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Gamma-hydroxybutyrate (GHB), a precursorto gamma aminobutyric acid (GABA), wasinitially employed as an anesthetic. As a relativelynovel drug, few people are aware of itsharmful effects and few studies have beenundertaken to investigate its long-term effectsor its action on developing tissues.We performed an experimental study onthe action of GHB on the developing eye, anorgan very closely related to the developmentof the CNS. Chick embryos were treated with20% or 30% dilutions of 100 ìl GHB at 7(30-31 HH) and 11 (37 HH) days of incubation(i.e., two doses per group), and the effectswere observed at 21 days of incubation (45HH). An ophthalmologic ultrasonographydevice (Hondex A/B SCAN IS-500) was usedto measure different eye parameters (cornealthickness; posterior surface of cornea – anteriorsurface of lens; anteroposterior diameter oflens; anteroposterior diameter of eye).We observed significant differencesbetween the treated and control groups asregards the thickness of the cornea and lens,and in the anteroposterior diameter of the eye.The present results demonstrate a possibleeffect of GHB on development (AU)
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Embrião de Galinha / Córnea / Ácido gama-Aminobutírico / Hidroxibutiratos Limite: Animais Idioma: Inglês Revista: Eur. j. anat Ano de publicação: 2008 Tipo de documento: Artigo Instituição/País de afiliação: University of Granada/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Embrião de Galinha / Córnea / Ácido gama-Aminobutírico / Hidroxibutiratos Limite: Animais Idioma: Inglês Revista: Eur. j. anat Ano de publicação: 2008 Tipo de documento: Artigo Instituição/País de afiliação: University of Granada/Spain
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