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Assessment of c-erbB 3 and c-erbB 4 expression in breast cancer patients and correlation with clinicopathological parameters
Koumoundourou, D; Michail, G; Zervoudis, S; Gerbesi, M; Iatrakis, G; Kourounis, G; Ravazoula, P.
Afiliação
  • Koumoundourou, D; Patras University Medical School. Greece
  • Michail, G; Patras University Medical School. Greece
  • Zervoudis, S; “Lito” Maternity Hospital. s.p
  • Gerbesi, M; Patras University Medical School. Greece
  • Iatrakis, G; Patras University Medical School. Greece
  • Kourounis, G; Patras University Medical School. Greece
  • Ravazoula, P; Patras University Medical School. Greece
Rev. senol. patol. mamar. (Ed. impr.) ; 19(4): 173-177, oct.-dic. 2006. ilus, tab
Artigo em En | IBECS | ID: ibc-63330
Biblioteca responsável: ES15.1
Localização: ES15.1 - BNCS
ABSTRACT
Objetive ErbB Receptor Tyrosine Kinases possess an establishedrole in mammary gland development and breast tumorigenesis.We aimed to assess the expression of c-erbB3and c-erbB4 RTKs in early breast carcinomas and investigateits possible correlation with Estrogen or Progesterone Receptors,tumor stage and grade, disease recurrence and patient’soutcome.Patients and

methods:

Forty-nine specimens of earlybreast carcinomas deriving from patients that had sustainedpartial or total mastectomy with axillary lymph node resectionwere studied retrospectively. Expression of RTKs was detectedimplementing a) an anti-HER-3 mouse polyclonal antibody;and b) an anti-HER-4 mouse polyclonal antibody. For both cerbB3and c-erbB4, either a cytoplasmic or a nuclear stainingpattern of tumor cells was considered positive.

Results:

Expression of c-erbB4 exhibited statistically significantassociation with tumor grade and unfavorable patient’soutcome. C-erbB3 expression did not correlate with tumorrecurrence or patient’s outcome.No association was established between the expression ofboth RTKs and that of Estrogen or Progesterone Receptors.C-erbB4 expression did not posess statistically significant associationwith patient’s death or disease recurrence. C-erbB3 expressiondid not correlate with tumor grade or recurrence andpatient’s death.

Conclusions:

In the context of compound molecularmechanisms, alterations in c-erbB3 and c-erbB4 expressionmerit appraisal as future interventions in breast cancer treatmen (AU)
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias da Mama / Proteínas Oncogênicas v-erbB Limite: Feminino / Humanos Idioma: Inglês Revista: Rev. senol. patol. mamar. (Ed. impr.) Ano de publicação: 2006 Tipo de documento: Artigo Instituição/País de afiliação: Patras University Medical School/Greece / “Lito” Maternity Hospital/s.p
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias da Mama / Proteínas Oncogênicas v-erbB Limite: Feminino / Humanos Idioma: Inglês Revista: Rev. senol. patol. mamar. (Ed. impr.) Ano de publicação: 2006 Tipo de documento: Artigo Instituição/País de afiliação: Patras University Medical School/Greece / “Lito” Maternity Hospital/s.p
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