Assessment of c-erbB 3 and c-erbB 4 expression in breast cancer patients and correlation with clinicopathological parameters
Rev. senol. patol. mamar. (Ed. impr.)
; 19(4): 173-177, oct.-dic. 2006. ilus, tab
Artigo
em En
| IBECS
| ID: ibc-63330
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ES15.1
Localização: ES15.1 - BNCS
ABSTRACT
Objetive ErbB Receptor Tyrosine Kinases possess an establishedrole in mammary gland development and breast tumorigenesis.We aimed to assess the expression of c-erbB3and c-erbB4 RTKs in early breast carcinomas and investigateits possible correlation with Estrogen or Progesterone Receptors,tumor stage and grade, disease recurrence and patientsoutcome.Patients and methods:
Forty-nine specimens of earlybreast carcinomas deriving from patients that had sustainedpartial or total mastectomy with axillary lymph node resectionwere studied retrospectively. Expression of RTKs was detectedimplementing a) an anti-HER-3 mouse polyclonal antibody;and b) an anti-HER-4 mouse polyclonal antibody. For both cerbB3and c-erbB4, either a cytoplasmic or a nuclear stainingpattern of tumor cells was considered positive.Results:
Expression of c-erbB4 exhibited statistically significantassociation with tumor grade and unfavorable patientsoutcome. C-erbB3 expression did not correlate with tumorrecurrence or patients outcome.No association was established between the expression ofboth RTKs and that of Estrogen or Progesterone Receptors.C-erbB4 expression did not posess statistically significant associationwith patients death or disease recurrence. C-erbB3 expressiondid not correlate with tumor grade or recurrence andpatients death.Conclusions:
In the context of compound molecularmechanisms, alterations in c-erbB3 and c-erbB4 expressionmerit appraisal as future interventions in breast cancer treatmen (AU)RESUMEN
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Neoplasias da Mama
/
Proteínas Oncogênicas v-erbB
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Rev. senol. patol. mamar. (Ed. impr.)
Ano de publicação:
2006
Tipo de documento:
Artigo
Instituição/País de afiliação:
Patras University Medical School/Greece
/
Lito Maternity Hospital/s.p