Parietaria sublingual allergoid immunotherapy with a co-seasonal treatment schedule
Allergol. immunopatol
; 36(2): 79-84, abr. 2008. ilus, tab
Artigo
em En
| IBECS
| ID: ibc-64439
Biblioteca responsável:
ES15.1
Localização: ES15.1 - BNCS
ABSTRACT
Background:
Sublingual immunotherapy (SLIT) with monomeric allergoid, given according to the standard scheme, resulted effective and safe. However, the achievement of a clinical benefit requires a long time. We thus performed this study using an administration protocol starting in the co-seasonal period with a 3-day build-up phase and lasting only 6 months, in order to obtain the above benefit in a shorter time. Methods andresults:
The study, prospective, randomised and controlled versus drug therapy, was conducted on 65 rhinitic and/or asthmatic patients allergic to Parietaria with or without other sensitisations. Twenty-four were allocated to 1,000 AU/week, 21 to 3,000 AU/week and 21 to drug therapy. They were treated from April to September 2006. At baseline, 3 and 6 months a Visual Analogue Scale (VAS) was performed to assess the patients' well-being. Drug consumption was evaluated by means of monthly diary cards. Bronchial reactivity was investigated at baseline and 6 months by methacholine challenge test. There was a greater VAS improvement in both the SLIT groups than in the controls after 6 months (p < 0.05). In patients taking 3,000 AU/week this was already evident after 3 months. There was a significant reduction in rescue medication consumption between 3 and 6 months (p < 0.05) in all three groups. The bronchial reactivity was reduced only in the SLIT groups (p < 0.001). No adverse events were observed.Conclusions:
At 6 months the allergoid SLIT showed itself to be effective and safe. In addition the subjective clinical benefit was obtained in a more rapid period, i.e. 3 instead of 6 months, when a higher maintenance dose was administeredRESUMEN
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Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Asma
/
Glândula Sublingual
/
Administração Sublingual
/
Rinite
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Rinite Alérgica Perene
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Parietaria
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Anafilaxia
/
Imunoterapia
/
Compostos de Metacolina
Tipo de estudo:
Ensaio clínico controlado
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Guia de prática clínica
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Estudo observacional
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Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
Medical Service Lofarma S.p.A./Italy
/
Papardo Hospital/Italy
/
Respiratory Centre Disease/Italy