Saccharomyces cerevisiae Rds2 transcription factor involvement in cell wall composition and architecture
Int. microbiol
; 11(1): 57-63, mar. 2008. ilus, tab
Artigo
em En
| IBECS
| ID: ibc-67267
Biblioteca responsável:
ES15.1
Localização: ES15.1 - BNCS
ABSTRACT
Although the cell wall is very important in yeasts, relatively little is known about the relationship between its structure and function. In Saccharomyces cerevisiae, a family of 55 transcription factor proteins unique to fungi, so-called zinc cluster proteins, has been described. Of these, Rds2 has been identified as an activator/inhibitor of gluconeogenesis. However, previous studies have pointed out additional roles for this protein, specifically, in the modulation of cell-wall architecture and drug sensitivity. In this work, evidence regarding the role of Rds2 as a regulator of cell-wall architecture and composition is presented based on phenotypical analysis of the cell walls prepared from a S. cerevisiae Rds2 mutant strain. Analyses of the sensitivity of this rds2Delta mutant to different drugs and to osmotic stress showed that Rds2 is indeed involved in the drug-sensitivity response and plays a role in determining osmotic sensitivity (AU)
RESUMEN
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Bases de dados nacionais
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Espanha
Base de dados:
IBECS
Assunto principal:
Saccharomyces cerevisiae
/
Fatores de Transcrição
Tipo de estudo:
Estudo prognóstico
Idioma:
Inglês
Revista:
Int. microbiol
Ano de publicação:
2008
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Valencia/España