Presence of fibronectin peptides in saliva of patients with Sjögren’s Syndrome: A potential indicator of salivary gland destruction

ABSTRACT

Objective: The purpose of this preliminary study was to monitor the degree of destruction of salivary glands inSjögren disease by the detection of fibronectin peptides in patients’ saliva. Study design: The sample consisted of10 subjects divided in 2 groups, one with Sjögren disease and a control group. Saliva samples were submitted to aninmunodetection analysis. In addition, non pathological salivary glands, obtained from 2 subjects who underwentminor oral surgery, were incubated with leukocyte homogenates and analysed to compare the obtained fragments.Results: The inmunodetection analysis of Sjögren saliva revealed multiple protein bands, including fibronectin,that were not present in saliva from healthy individuals. The inmunostained bands varied depending on the courseof the disease, showing more fibronectin fragments in an active phase . Furthermore, results obtained from thenon-pathological glands incubated with leukocyte homogenates were similar to those revealed in saliva from Sjögrenpatients. Conclusion: The presence of fibronectin peptides in Sjögren patients’ saliva can constitute a methodto monitor activity in Sjögren’s disease (AU)

RESUMEN

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