Formulation and evaluation of sustained release microspheres of rosin containing aceclofenac
Ars pharm
; 50(2): 51-62, abr.-jun. 2009. tab, ilus, graf
Artigo
em Inglês
| IBECS
| ID: ibc-73677
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Aceclofenac was microencapsulated using rosin by o/w emulsion solvent evaporationtechnique. The effect of three formulation variables including the drugpolymer ratio,emulsifier (polyvinyl alcohol) concentration and organic solvent (dichloromethane) volumewere examined. The prepared batches were characterized for microspheres particle sizedistribution, encapsulation efficiency and in vitro release behavior. The study reveals thatdrugpolymer ratio had a considerable effect on the entrapment efficiency, however particlesize distribution of microspheres was more dependent on the volume of dichloromethane andpolyvinyl alcohol concentration rather than on the drug polymer ratio. Drug, polymerconcentrations were varied to obtain optimum release profile for sustaining the action of thedrug(AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Fenilacetatos
/
Anti-Inflamatórios não Esteroides
/
Microesferas
Idioma:
Inglês
Revista:
Ars pharm
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Manipal University/India