Effects of reserpine and p-chloroamphetamine on5-HT metabolism and release in the cerebralganglia of Inachis io (Lepidoptera)
J. physiol. biochem
; 63(2): 129-142, abr.-jun. 2007. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-76670
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
There have been few pharmacological studies of serotonergic system dynamics ininsects. A more precise knowledge of the response of serotonergic neurons to drugswill contribute to understanding of the role of this neurotransmitter in insect behaviour.The present work was carried out to study several aspects of serotonin (5-HT)metabolism and release in an insect, the butterfly Inachis io. The effects of a singleintra-abdominal injection of reserpine (30 ìg/insect) or p-chloroamphetamine (50ìg/insect) on cerebral ganglia 5-HT metabolism and release were studied. Afterreserpine injection a depletion of 5-HT stores concomitant with an increase in Nacetylserotoninlevels was observed, but not significant alteration of extraneuronal 5-HT release was observed. Administration of p-chloroamphetamine (PCA) inducedextraneuronal 5-HT release, together with inhibition of its reuptake. Finally, a singleinjection of p-chloroamphetamine in reserpine-treated insects was able to induce newrelease of 5-HT. Reserpine interferes with the vesicular storage of 5-HT, but does notaffect the process of neuronal release, while PCA induces the synaptic release of 5-HT and inhibits its reuptake. These effects are similar to those observed in mammals (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
P-Cloroanfetamina
/
Reserpina
/
Telencéfalo
/
Serotonina
/
Gânglios
/
Lepidópteros
Limite:
Animais
Idioma:
Inglês
Revista:
J. physiol. biochem
Ano de publicação:
2007
Tipo de documento:
Artigo
Instituição/País de afiliação:
Universidad de Santiago de Compostela/España