Formulation, Evaluation and Optimization of Fast Dissolving Tablets Containing Amlodipine Besylate by Sublimation Method
Ars pharm
; 50(3): 129-144, jul.-sept. 2009. ilus, tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-77751
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The objective of this research was to formulate fast dissolving tablet of amlodipine besylate for rapid action. Sublimation method was adapted to prepare the tablets by using a 23 full factorial design. FT-IR and D.T.A studies revealed that there was no physico-chemical interaction between amlodipine besylate and other excipients. All formulations are evaluated for pre-compression and post-compression parameters, wetting time, water absorption ratio. The results obtained showed that the quantity of starch potato, sodium starch glycolate, camphor significantly affect response variables. The results indicate that the optimized tablet formulation provides a short DT of 8 sec with sufficient crushing strength and acceptable friability. Stability studies of optimized formulation revealed that formulation is stable(AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Comprimidos
/
Cânfora
/
Anlodipino
Limite:
Humanos
Idioma:
Inglês
Revista:
Ars pharm
Ano de publicação:
2009
Tipo de documento:
Artigo
Instituição/País de afiliação:
Cherraans college of pharmacy/India
/
Department of Pharmaceutics, Visveswarapura Institute of Pharmaceutical Sciences/India
/
Nirmala college of pharmacy/India