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Fibronectin as an adjuvant in the diagnosis of oral inflammatorymyofibroblastic tumor
Xavier, Flávia-Caló-Aquino; Rocha, André-Caroli; Sugaya, Norberto-Nobuo; Santos-Pinto Jr, Décio dos; Sousa, Suzana Cantanhede Orsini-Machado de.
Afiliação
  • Xavier, Flávia-Caló-Aquino; University of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo. Brazil
  • Rocha, André-Caroli; University of São Paulo. School of Dentistry. Department of Stomatology. São Paulo. Brazil
  • Sugaya, Norberto-Nobuo; University of São Paulo. School of Dentistry. Department of Stomatology. São Paulo. Brazil
  • Santos-Pinto Jr, Décio dos; University of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo. Brazil
  • Sousa, Suzana Cantanhede Orsini-Machado de; University of São Paulo. School of Dentistry. Department of Oral Pathology. São Paulo. Brazil
Med. oral patol. oral cir. bucal (Internet) ; 14(12): 635-639, dic. 2009. ilus
Artigo em Inglês | IBECS | ID: ibc-78748
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Inflammatory myofibroblastic tumor is a distinctive lesion composed of myofibroblastic spindle shaped cells accompaniedby inflammatory infiltrate that may arise in various organs. It is believed to be a noneoplastic inflammatorycondition, although this is still controversial. The recognition of inflammatory myofibroblastic tumor asan entity is important especially to avoid unnecessary surgery. A few cases have been reported in the oral cavity.This report primarily presents a case of inflammatory myofibroblastic tumor that arose in the floor of mouth ofa 23-year-old woman. The proliferating spindle cells were immunoreactive for vimentin, smooth muscle actin,and muscle specific actin and negative for desmin, AE1/AE3, S-100, CD68, MyoD1 and caldesmon. In an attemptto assess the potential neoplastic nature of this lesion, immunohistochemical expression of ALK protein wasperformed, although no immunoreactivity was detected. Also, the presence of well differentiated myofibroblastsidentified by fibronectin is discussed, as well as the importance in establishing an immunoprofile to better consolidatethe diagnosis. We conclude that the study of fibronectin in case series may aid the diagnosis as well as theprediction of the tumor course (AU)
RESUMEN
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Assuntos
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias Bucais / Fibronectinas Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2009 Tipo de documento: Artigo Instituição/País de afiliação: University of São Paulo/Brazil
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Neoplasias Bucais / Fibronectinas Tipo de estudo: Estudo diagnóstico Limite: Feminino / Humanos Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2009 Tipo de documento: Artigo Instituição/País de afiliação: University of São Paulo/Brazil
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