Macroscopic small bowel mucosal injury caused by chronic nonsteroidal anti-inflammatory drugs (NSAID) use as assessed by capsule endoscopy
Rev. esp. enferm. dig
; 102(2): 80-85, feb. 2010. ilus, tab
Artigo
em Espanhol
| IBECS
| ID: ibc-78882
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objective:
to evaluate the type, frequency, and severity of macroscopicsmall bowel mucosal injury after chronic NSAID intake asassessed by capsule endoscopy (CE), as well as to correlate the severityof gastroduodenal and intestinal damage in these patients.Material andmethods:
a prospective, endoscopist-blind,controlled trial. Sixteen patients (14F/2M; age 57.06 ± 10.16yrs) with osteoarthritis (OA) on chronic therapy with NSAIDs underwentCE and upper gastrointestinal endoscopy (UGE). Seventeenpatients with OA (9F/2M; age 57.47 ± 9.82 yrs) who didnot take NSAIDs were included as a control group. A scale rangingfrom 0 to 2 (0 = no lesions, 1-minor = red spots or petechiae,denuded areas and/or 1-5 mucosal breaks; 2-major = > 5mucosal breaks and/or strictures, or hemorrhage) was designed toassess the severity of small bowel mucosal injuries.Results:
CE found intestinal lesions in 75% (12/16) of patientsin the study group and in 11.76% (2/17) of controls (p <0.01). Seven out of 16 NSAID consumers (43.75%) and none inthe control group (0%) had a major small bowel mucosal injury (p< 0.01). The percentages of patients with grade 1 and 2 gastroduodenopathyin the study group, as assessed by UGE, were37.14 and 23.81%, respectively. There was no significant differencein the rate of major enteropathy between patients withnone or minor gastroduodenal injury, and those with major gastroduodenopathy(43.75 vs. 40%; p = N.S.).Conclusions:
chronic NSAID intake is associated with a highrate of small bowel mucosal injuries. Our data have failed to demonstratea relationship between the severity of gastroduodenaland intestinal injury(AU)
Texto completo:
Disponível
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Gastropatias
/
Anti-Inflamatórios não Esteroides
/
Diclofenaco
/
Ibuprofeno
/
Duodenopatias
/
Endoscopia por Cápsula
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Espanhol
Revista:
Rev. esp. enferm. dig
Ano de publicação:
2010
Tipo de documento:
Artigo
Instituição/País de afiliação:
University Hospital Virgen Macarena/Spain