Your browser doesn't support javascript.
loading
Montelukast treatment (cysteinyl leukotriene receptor antagonist) in a model of food allergy: modifications in lymphatic cell population from rectal mucosa
Vinuesa, M; Bassan, N; Cases, A. I; Krumrik, G.
Afiliação
  • Vinuesa, M; Universidad Nacional de Rosario. Rosario. Argentina
  • Bassan, N; Universidad Nacional de Rosario. Rosario. Argentina
  • Cases, A. I; Universidad Nacional de Rosario. Rosario. Argentina
  • Krumrik, G; Universidad Nacional de Rosario. Rosario. Argentina
Rev. esp. enferm. dig ; 102(7): 421-425, jul. 2010. tab, ilus
Artigo em Inglês | IBECS | ID: ibc-80482
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

Objective:

the aim is to determine immunopathological modifications in rectal mucosa from rabbits after local challenge in ovalbumin (OVA) sensitized animals previously treated with montelukast. Material and

methods:

experimental

design:

thirty two rabbits divided into four groups G1 normal; G2 subcutaneously OVA sensitized; G3 sensitized, locally OVA challenged and sampled 4 hours after challenge; and G4 sensitized, locally OVA challenged and treated 4 hours before challenge with montelukast (0.15 mg/kg). Specific anti-OVA IgE levels were evaluated by passive cutaneous anaphylaxis test (PCA). In each group 200 high microscopical power fields (HPF) were counted. Results were expressed as arithmetic mean and SE. Anti -CD4, CD5, micro chain monoclonal antibodies were used. Avidin biotin horseradish peroxidase system was used.

Results:

CD 4 G1 8.3 ± 0.06; G2 13.4 ± 0.08, G3 8.25 ± 0.06, G4 11.8 ± 0.02. CD 5 G1 7.3 ± 0.05; G2 9.4 ± 0.05, G3 11.3 ± 0.06, G4 8.1 ± 0.06. ì chain G1 10.4 ± 0.06; G2 3.8 ± 0.02, G3 6.0 ± 0.10, G4 2.2 ± 0.10. In all cases, experimental groups (G3 vs. G4) presented statistical significant differences (p < 0.05). CD4+, CD5+ cells and micro chain+ decrease in experimental group (G4), probably due to lymphocyte migration inhibition to challenged mucosa. micro chain+ cell decrease could be based on B cell activation and expression of different surface immunoglobulins. Cells expressing micro chain decreased in G2 and G3 likely due to activation of B cells and subsequent expression of other immunoglobulin chains in cell surface.

Conclusions:

we conclude that obtained data are important to elucidate immunopathology of local anaphylactic reaction in rectal mucosa from systemic sensitized animals after treatment with montelukast(AU)
Assuntos
Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Imuno-Histoquímica / Ovalbumina / Antagonistas de Leucotrienos / Hipersensibilidade Alimentar / Acetatos / Anticorpos Monoclonais Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Rev. esp. enferm. dig Ano de publicação: 2010 Tipo de documento: Artigo Instituição/País de afiliação: Universidad Nacional de Rosario/Argentina
Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Imuno-Histoquímica / Ovalbumina / Antagonistas de Leucotrienos / Hipersensibilidade Alimentar / Acetatos / Anticorpos Monoclonais Tipo de estudo: Estudo prognóstico Limite: Animais Idioma: Inglês Revista: Rev. esp. enferm. dig Ano de publicação: 2010 Tipo de documento: Artigo Instituição/País de afiliação: Universidad Nacional de Rosario/Argentina
...