Pulmonary complications in patients with antibody deficiency
Allergol. immunopatol
; 39(3): 128-132, mayo-jun. 2011. tab, graf
Artigo
em Inglês
| IBECS
| ID: ibc-90099
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objective:
The aim of this study was to evaluate pulmonary complications in patients with primary antibody deficiency (X-linked a gammaglobulinaemia [XLA] and common variable immunodeficiency [CVID]).Methods:
Thirty patients over six years of age regularly followed in a reference out-patient clinic on primary immunodeficiency were studied. All of them have been treated with intravenous immunoglobulin (IVIG) replacement therapy. Pulmonary complications were evaluated analysing clinical data (medical records review), lung function test (spirometry) and pulmonary imaging (chest computed tomography [CCT]).Results:
Patients with normal CCT (N=14) and those with abnormal CCT (N=16) have shown no differences regarding the age at onset of symptoms, age of diagnosis, and duration of IVIG treatment. The mean number of pneumonia episodes before IVIG replacement was significantly higher among patients with abnormal CCT (4 vs 7 episodes, p=0.008). CCT abnormalities observed in 16 patients were bronchiectasis (12/16); peribronchial thickening (3/16); airtrapping (5/16); lung volume reduction (4/16); atelectasis (2/16), follicular bronchiolitis and ground-glass abnormality (2/16) and parenchyma nodule (1/16). Lung function tests showed ventilatory disturbance in 18/30 obstructive pattern in 38.8%, restrictive pattern in 44.4%,and mix pattern in 16.7%. There were no significant differences in lung function between those with and without CCT abnormalities. Negative significant correlations were observed between lung function and number of episodes of pneumonia. Chronic persistent cough was associated with a reduction in lung function.Conclusions:
Pulmonary complications are not rare in patients with antibody deficiencies and they must be monitored (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Contexto em Saúde:
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Problema de saúde:
Pneumonía
Base de dados:
IBECS
Assunto principal:
Imunodeficiência de Variável Comum
/
Agamaglobulinemia
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Allergol. immunopatol
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Clinical Immunology and Rheumatology/Brazil