Investigation of interleukin-1 alpha and interleukin-6 expressionand interleukin-1 alpha gene polymorphism in keratocysticodontogenic tumors and ameloblastomas

ABSTRACT

Objective: In jawbones, ameloblastomas and odontogenic keratocysts share many clinical features in commonsuch as aggressiveness, high recurrence rates and radical management options. Understanding the pathogenesisand biological aspects of these tumors would improve the success of diagnose and treatment procedures. Theaim of this study was to exhibit the reasons of high recurrence rates and growth potentials of ameloblastomas andkeratocystic odontogenic tumours by investigating the expression of IL-1α and IL-6 and IL-1α -889 gene polymorphism.IL-1α and IL-6 are shown as very effective tissue degrading factors in bone remodelling.Study Design: This study included 25 cases of ameloblastomas, 41 cases of keratocystic odontogenic tumors (parakeratinizedodontogenic keratocysts) and 8 cases of orthokeratinized odontogenic keratocysts. All histologicalslides were stained immunohistochemically to show the expression of IL-1α and IL-6. Restriction fragment lengthanalysis was used to investigate the cytokine gene polymorphism.Results and Conclusions: The higher expression rates of IL-1α and IL-6 were associated with tumor size in ameloblastomasand with cyst wall thickness in keratocystic odontogenic tumors. This finding suggested us that thecytokines IL-1α and IL-6 play a role on aggressive behaviour of ameloblastomas and keratocystic odontogenictumors by making easy bone resorption. In addition, IL-1α (-889) T polymorphism was found consistent withincreased IL-1α expression but not seem as a risk factor on the development of these tumors (AU)