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Interaction between â-amyloid protein andthe á7 nicotinic acetylcholine receptorin cholinergic, gabaergic and calcium-bindingproteins-containing neurons in theseptum-diagonal band complex of the rat
Gonzalo-Ruiz, A; Arévalo-Serrano, J.
Afiliação
  • Gonzalo-Ruiz, A; University of Valladolid. Institute of Neuroscience of Castilla and León. Laboratory of Neuroanatomy. Soria. Spain
  • Arévalo-Serrano, J; University of Alcala de Henares. Medical School. Department of Pathology. Madrid. Spain
Eur. j. anat ; 10(3): 127-142, dic. 2006. ilus
Artigo em Inglês | IBECS | ID: ibc-93384
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
The effects of intracerebral injection of thebeta-amyloid protein (Aâ1-40) on the á7subtype of nicotinic acetylcoline receptor protein(nAChR) in neurons of the septum-diagonalband (MS-nDBB) complex were studiedin rats. Focal deposition of Aâ in the retrosplenialcortex resulted in a selective reductionin the number of á7nAChR-immunoreactivecells in different parts of the MS-nDBB complex,especially in the horizontal nucleus ofthe diagonal band of Broca (HDB). The analysisrevealed a significant decrease of 37.27%in the number of á7nAChR-immunoreactivecells in the HDB ipsilateral to the Aâ-injectedside as compared to the correspondinghemisphere of non-treated control animals,and a reduction of 31.55% was observed inthe HDB ipsilateral to the Aâ-injected side ascompared to the contralateral HDB, whichcorresponds to the control (PBS)-injected side.A significant reduction (up to 20%) ofá7nAChR-containing neurons was also foundin the medial septal nucleus when comparedwith the corresponding hemisphere in nontreatedcontrol animals. The results alsorevealed that á7nAChR-positive immunoreactivityis highly localized within cytoplasmicgranules in cholinergic neurons and in a smallsubset of putative GABAergic cells of the MSnDBBcomplex. In conclusion, these findingssuggest an interaction of Aâ1-40 with theá7nAChR, which may contribute to impairmentsin cholinergic and GABAergic transmissionin the MS-nDBB complex (AU)
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Peptídeos beta-Amiloides / Receptores Nicotínicos / Doença de Alzheimer Limite: Animais Idioma: Inglês Revista: Eur. j. anat Ano de publicação: 2006 Tipo de documento: Artigo Instituição/País de afiliação: University of Alcala de Henares/Spain / University of Valladolid/Spain
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Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Peptídeos beta-Amiloides / Receptores Nicotínicos / Doença de Alzheimer Limite: Animais Idioma: Inglês Revista: Eur. j. anat Ano de publicação: 2006 Tipo de documento: Artigo Instituição/País de afiliação: University of Alcala de Henares/Spain / University of Valladolid/Spain
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