Interaction between â-amyloid protein andthe á7 nicotinic acetylcholine receptorin cholinergic, gabaergic and calcium-bindingproteins-containing neurons in theseptum-diagonal band complex of the rat
Eur. j. anat
; 10(3): 127-142, dic. 2006. ilus
Artigo
em Inglês
| IBECS
| ID: ibc-93384
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
The effects of intracerebral injection of thebeta-amyloid protein (Aâ1-40) on the á7subtype of nicotinic acetylcoline receptor protein(nAChR) in neurons of the septum-diagonalband (MS-nDBB) complex were studiedin rats. Focal deposition of Aâ in the retrosplenialcortex resulted in a selective reductionin the number of á7nAChR-immunoreactivecells in different parts of the MS-nDBB complex,especially in the horizontal nucleus ofthe diagonal band of Broca (HDB). The analysisrevealed a significant decrease of 37.27%in the number of á7nAChR-immunoreactivecells in the HDB ipsilateral to the Aâ-injectedside as compared to the correspondinghemisphere of non-treated control animals,and a reduction of 31.55% was observed inthe HDB ipsilateral to the Aâ-injected side ascompared to the contralateral HDB, whichcorresponds to the control (PBS)-injected side.A significant reduction (up to 20%) ofá7nAChR-containing neurons was also foundin the medial septal nucleus when comparedwith the corresponding hemisphere in nontreatedcontrol animals. The results alsorevealed that á7nAChR-positive immunoreactivityis highly localized within cytoplasmicgranules in cholinergic neurons and in a smallsubset of putative GABAergic cells of the MSnDBBcomplex. In conclusion, these findingssuggest an interaction of Aâ1-40 with theá7nAChR, which may contribute to impairmentsin cholinergic and GABAergic transmissionin the MS-nDBB complex (AU)
RESUMEN
No disponible
Buscar no Google
Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Peptídeos beta-Amiloides
/
Receptores Nicotínicos
/
Doença de Alzheimer
Limite:
Animais
Idioma:
Inglês
Revista:
Eur. j. anat
Ano de publicação:
2006
Tipo de documento:
Artigo
Instituição/País de afiliação:
University of Alcala de Henares/Spain
/
University of Valladolid/Spain