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Screening and evaluation of antiparasitic and in vitro anticancer activities of Panamanian endophytic fungi
Sergio Martínez-Luis, Sergio; Cherigo, Lilia; Higginbotham, Sarah; Arnold, Elizabeth; Spadafora, Carmenza; Ibañez, Alicia; Gerwick, William H; Cubilla-Rios, Luis.
Afiliação
  • Sergio Martínez-Luis, Sergio; Institute for Advanced Scientific Research and High Technology Services. Center for Drug Discovery. Panama
  • Cherigo, Lilia; University of Panama. Faculty of Natural, Exact Sciences and Technology. Laboratory of Tropical Bioorganic Chemistry. Panama
  • Higginbotham, Sarah; Smithsonian Tropical Research Institute. Panama
  • Arnold, Elizabeth; University of Arizona. School of Plant Sciences. Division of Plant Pathology and Microbiology. USA
  • Spadafora, Carmenza; Institute for Advanced Scientific Research and High Technology Services. Center for Cellular & Molecular Biology of Diseases. Panama
  • Ibañez, Alicia; Smithsonian Tropical Research Institute. Panama
  • Gerwick, William H; University of California. Skaggs School of Pharmacy and Pharmaceutical Sciences. San Diego. USA
  • Cubilla-Rios, Luis; University of Panama. Faculty of Natural, Exact Sciences and Technology. Laboratory of Tropical Bioorganic Chemistry. Panama
Int. microbiol ; 14(2): 95-102, jun. 2011. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-93477
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT
Many compounds produced by fungi have relevant pharmaceutical applications. The purpose of this study was to collect and isolate endophytic fungi from different regions of Panama and then to test their potential therapeutic activities against Leishmania donovani, Plasmodium falciparum, and Trypanosoma cruzi as well as their anticancer activities in MCF-7 cells. Of the 25 fungal isolates obtained, ten of them had good anti-parasitic potential, showing selective activity against L. donovani; four had significant anti-malarial activity; and three inhibited the growth of T. cruzi. Anticancer activity was demonstrated in four isolates. Of the active isolates, Edenia sp. strain F0755, Xylaria sp. strain F1220, Aspergillus sp. strain F1544, Mycoleptodiscus sp. strain F0194, Phomopsis sp. strain F1566, Pycnoporus sp. strain F0305, and Diaporthe sp. strain F1647 showed the most promise based on their selective bioactivity and lack of toxicity in the assays (AU)
RESUMEN
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Coleções: Bases de dados nacionais / Espanha Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Doença de Chagas / Malária / Doenças Negligenciadas Base de dados: IBECS Assunto principal: Fungos / Antineoplásicos / Antiparasitários Tipo de estudo: Estudo diagnóstico / Estudo de rastreamento Idioma: Inglês Revista: Int. microbiol Ano de publicação: 2011 Tipo de documento: Artigo Instituição/País de afiliação: Institute for Advanced Scientific Research and High Technology Services/Panama / Smithsonian Tropical Research Institute/Panama / University of Arizona/USA / University of California/USA / University of Panama/Panama
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Coleções: Bases de dados nacionais / Espanha Contexto em Saúde: Doenças Negligenciadas Problema de saúde: Doença de Chagas / Malária / Doenças Negligenciadas Base de dados: IBECS Assunto principal: Fungos / Antineoplásicos / Antiparasitários Tipo de estudo: Estudo diagnóstico / Estudo de rastreamento Idioma: Inglês Revista: Int. microbiol Ano de publicação: 2011 Tipo de documento: Artigo Instituição/País de afiliação: Institute for Advanced Scientific Research and High Technology Services/Panama / Smithsonian Tropical Research Institute/Panama / University of Arizona/USA / University of California/USA / University of Panama/Panama
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