Oral contraceptive use and salivary C-erbB-2, CEA and CA15-3in healthy women: A Case-Control Study
Med. oral patol. oral cir. bucal (Internet)
; 16(1): e29-e32, ene. 2011. tab
Artigo
em Inglês
| IBECS
| ID: ibc-95835
Biblioteca responsável:
ES1.1
Localização: BNCS
ABSTRACT
Objectives:
Oral contraceptives (OCP) are highly effective, safe and widely used. Higher exposure to endogenous and exogenous estrogens is generally thought to increase the risk of breast cancer. Therefore, this study was conducted to determine if oral contraceptive use affected the expression of CA 15-3, CEA and C-erb B-2 in the saliva of healthy women.Studydesign:
The participants consisted of 87 healthy women (43 controls and 44 using oral contraceptives) ranging in age from 20 to 54 years. The volunteers participated by giving one time stimulated whole saliva samples.Then the samples were analysed for CA 15-3, CEA and C-erb B-2 concentrations.Results:
The student t-test was used to compare group means for variables with comparable variability. The meanof C-erb B-2, CEA, and CA 15-3 concentrations (in the case and control groups) was (1.93, 1.70), (34.46, 31.62) and(12.58, 16.19) respectively. These differences were not statistically significant.Conclusions:
Our findings suggest that the levels of the cancer biomarkers C-erb B-2, CEA and CA 15-3 were not affected by increased levels of estrogens in the body (AU)
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Coleções:
Bases de dados nacionais
/
Espanha
Base de dados:
IBECS
Assunto principal:
Saliva
/
Antígeno Carcinoembrionário
/
Receptor ErbB-2
/
Mucina-1
/
Anticoncepcionais Orais
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Med. oral patol. oral cir. bucal (Internet)
Ano de publicação:
2011
Tipo de documento:
Artigo
Instituição/País de afiliação:
Hamadan University of Medical Sciences/Iran
/
Shaheed Beheshti University of Medical Sciences/Iran