Your browser doesn't support javascript.
loading
CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma
Silva, Luan César Da; Fonseca, Felipe Paiva; Almeida, Oslei Paes de; Mariz, Bruno Augusto A; Lopes, Márcio Ajudarte; Radhakrishnan, Raghu; Sharma, Mohit; Kowalski, Luz Paulo; Vargas, Pablo Agustin.
Afiliação
  • Silva, Luan César Da; University of Campinas. Department of Oral Diagnosis of Piracicaba Dental School. São Paulo. Brazil
  • Fonseca, Felipe Paiva; University of Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Minas Gerais. Brazil
  • Almeida, Oslei Paes de; University of Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Minas Gerais. Brazil
  • Mariz, Bruno Augusto A; University of Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Minas Gerais. Brazil
  • Lopes, Márcio Ajudarte; University of Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Minas Gerais. Brazil
  • Radhakrishnan, Raghu; Manipal Academy of Higher Education. Department of Oral Pathology and Microbiology. Manipal. India
  • Sharma, Mohit; Sudha Rustagi College of Dental Sciences and Research. Department of Oral Pathology. Faridabad. Inida
  • Kowalski, Luz Paulo; A. C. Camargo Cancer Center. Department of Head and Neck Surgery and Otorhinolaryngology. São Paulo. Brazil
  • Vargas, Pablo Agustin; University of Minas Gerais. School of Dentistry. Department of Oral Surgery and Pathology. Minas Gerais. Brazil
Med. oral patol. oral cir. bucal (Internet) ; 25(1): e49-e55, ene. 2020. ilus, tab, graf
Artigo em Inglês | IBECS | ID: ibc-196195
Biblioteca responsável: ES1.1
Localização: BNCS
ABSTRACT

BACKGROUND:

The objective of this study investigated the distribution of immature dendritic cells (DCs), Langer-hans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). MATERIAL AND

METHODS:

Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL ̧ 45 of OSCC and 8 of normal epi-thelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified.

RESULTS:

A significant decrease of CD1a+ was found in OSMF (p≤0.05), OSMF-OSCC (p ≤ 0.01), and OSCC (p ≤ 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ≤ 0.05), and OSCC (p ≤ 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ≤ 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium.

CONCLUSION:

The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation
RESUMEN
No disponible
Assuntos

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Fibrose Oral Submucosa / Células Dendríticas / Leucoplasia Oral / Neoplasias Bucais / Carcinoma de Células Escamosas Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: A. C. Camargo Cancer Center/Brazil / Manipal Academy of Higher Education/India / Sudha Rustagi College of Dental Sciences and Research/Inida / University of Campinas/Brazil / University of Minas Gerais/Brazil

Texto completo: Disponível Coleções: Bases de dados nacionais / Espanha Base de dados: IBECS Assunto principal: Fibrose Oral Submucosa / Células Dendríticas / Leucoplasia Oral / Neoplasias Bucais / Carcinoma de Células Escamosas Limite: Adulto / Idoso / Feminino / Humanos / Masculino Idioma: Inglês Revista: Med. oral patol. oral cir. bucal (Internet) Ano de publicação: 2020 Tipo de documento: Artigo Instituição/País de afiliação: A. C. Camargo Cancer Center/Brazil / Manipal Academy of Higher Education/India / Sudha Rustagi College of Dental Sciences and Research/Inida / University of Campinas/Brazil / University of Minas Gerais/Brazil
...