HLA y diabetes mellitus insulino-dependiente / HLA and insulin-dependent diabetes mellitus
Rev. méd. Chile
; 122(12): 1413-20, dic. 1994. tab, ilus
Artigo
em Espanhol
| LILACS
| ID: lil-144181
Biblioteca responsável:
CL1.1
ABSTRACT
The propensity of an individual to develop type I (insulin dependent) diabetes mellitus is directly related to specipic HLA clase II proteins, specially those from DR and DQ regions. Genetic susceptibility to insulin dependent diabetes arises from a preestablished conformation of alpha and ß chains of DQ and ß chain of DR. Since the classic demonstration by McDevitt and colleagues that DQ ß chain aspartate at position 57 was protective against the development of the disease, many populations have been surveyed to study the association between the incidence Type I diabetes and determined frequencies of DR and DQ haplotypes. The assocation between these markers and susceptibility to Type I diabetes is well established in caucasians at the present time. However, little information is available for Latin American populations, that share a mixture of european, african and native genes. Our group is studying genetic markers of three Latin American populations (Argentina, Perú and Chile) and their possible association to the different incidence of Type I diabetes mellitus in each country
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Antígenos HLA-DP
/
Antígenos HLA-DQ
/
Antígenos HLA-DR
/
Diabetes Mellitus Tipo 1
/
Complexo Principal de Histocompatibilidade
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Humanos
Idioma:
Espanhol
Revista:
Rev. méd. Chile
Assunto da revista:
Medicina
Ano de publicação:
1994
Tipo de documento:
Artigo