Lipid effects on nicotinic acetylcholine receptor gating and kinetics: a structural-functional correlation
Braz. j. med. biol. res
; 26(6): 553-71, Jun. 1993. tab
Artigo
em Inglês
| LILACS
| ID: lil-148709
Biblioteca responsável:
BR1.1
ABSTRACT
The nicotinic acetylcholine receptor (AChR) is still the paradigm of rapid ligand-gated ion channels. Since the early finding of a motionally restricted shell of lipids ( annulus ) in the immediate perimeter of the membrane-bound AChR, experimental evidence has supported the notion that the interface between the protein moiety and the adjacent lipid molecules is the site of action of a variety of pharmacologically relevant substances, including non-competitive inhibitors of the cholinergic system like some local anesthetics, short-chain alcohols, and steroids. Patch-clamp data on cells expressing the AChR protein add another dimension to this knowledge, enabling correlations to be established between the chemical composition of lipid-modified cells and the functional properties (ligand binding, channel gating) of the receptor protein in situ
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Ativação do Canal Iônico
/
Receptores Nicotínicos
/
Lipídeos de Membrana
Limite:
Animais
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Assunto da revista:
Biologia
/
Medicina
Ano de publicação:
1993
Tipo de documento:
Artigo