"In vivo" and "in vitro" antitumoral action of Larrea divaricata cav
Acta physiol. pharmacol. ther. latinoam
; 46(1): 33-40, 1996. tab, graf
Artigo
em Inglês
| LILACS
| ID: lil-168104
Biblioteca responsável:
BR1.1
ABSTRACT
We previously reported that aqueous extract of Larrea divaricata Cav had an antiproliferative activity upon tumoral lymphoid cells (BW 5147), without affecting normal immunity. To determine the probable mechanism of the inhibitory action of the extract upon cell growth, the participation of intracellular signals involved in the inhibition of cell proliferation, namely the activation of adenylate cyclase system was studied. The production of cyclic 3', 5 adenosine monophosphate (cAMP) in presence and absence of extract was analized. The extract increased the cAMP levels, but neither the cAMP production nor the inhibitory effect of the extract on proliferation were blocked by a beta adrenergic receptor antagonist (propranolol) or by histaminergic receptor antagonistis (cimetidine and mepyramine). So, we concluted that the antiproliferative activity of the extract of BW 5147 cells would be mediated by an increase in cAMP intracellular levels no related to the activation of the membrane receptors here studied. In parallel, the extract was administered to a pregnant rat with a spontaneous mammarian carcinoma and "in vivo"antitumoral activity was found.
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Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Plantas Medicinais
/
Extratos Vegetais
/
Carcinoma
/
Neoplasias Mamárias Animais
/
Divisão Celular
/
Linfoma de Células T
/
AMP Cíclico
/
Antineoplásicos Fitogênicos
Limite:
Animais
/
Gravidez
Idioma:
Inglês
Revista:
Acta physiol. pharmacol. ther. latinoam
Assunto da revista:
Farmacologia
/
Fisiologia
/
Terapêutica
Ano de publicação:
1996
Tipo de documento:
Artigo
/
Documento de projeto