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Enfermedad de los tics: síndrome de Gilles de la Tourette: características clínicas de 70 pacientes / Gilles de la Touretteïs syndrome: clinical review and analysis of 70 chilean patients
Miranda Cabezas, Marcelo; Menéndez G., Pedro; David G., Perla; Troncoso S., Mónica; Hernández C., Marta; Chaná Cuevas, Pedro.
Afiliação
  • Miranda Cabezas, Marcelo; s.af
  • Menéndez G., Pedro; s.af
  • David G., Perla; s.af
  • Troncoso S., Mónica; s.af
  • Hernández C., Marta; s.af
  • Chaná Cuevas, Pedro; s.af
Rev. méd. Chile ; 127(12): 1480-6, dic. 1999. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-258073
Biblioteca responsável: CL1.1
ABSTRACT

Background:

Tourette's syndrome is a childhood-onset hereditary neurobehavioural disorder believed to occur without geographical restrictions. Although there have been reports of this disorder worldwide just a few are from Latin America.

Aim:

To report a preliminary experience with a series of 70 patients and to review recent advances in this disorder. Patients and

Method:

We reviewed patients seen in pediatric and adult neurological clinics in Santiago, Chile, all of whom fulfilled clinical diagnostic criteria for Tourette Syndrome.

Results:

Seventy patients were studied, 54 males (77.1 percent) and 16 females (22.8 percent), their mean age at first evaluation was 13.6 years (range 2-46). The mean age of onset of symptoms was 6.4 (range 2-20), the mean time of follow-up was 3 years. Fifty-eight patients showed simple motor tics (blinking, facial grimacing, shoulder shrugging), whereas dystonic tics like head jerking were seen in 38 patients, torticollis in 6 and oculogyric movements in 2. Complex motor tics like jumping, antics, trunk bending and head shaking were present in 16 subjects. Vocal tics were predominantly of the simple type sniffing, throat clearing, blowing, and whistling. Complex vocal tics were seen in 12 patients, five cases showed palilalia, 3 echolalia and only six displayed coprolalia (8.5 percent). Tics were of mild to moderate severity in most patients. Obsessive-compulsive disorder was observed in 22.8 percent and attention deficit and hyperactivity disorder were present in 35.7 percent. Forty-five patients (64.2 percent) had a first degree relative with tics, nine patients (12.8 percent) had a family history of obsessive-compulsive disorder. The current evidence involving desinhibition of cortico-striatum-thalamic-cortical neuronal circuits in the pathogenesis of this disorder is analyzed.

Conclusion:

Our report supports the recognized clinical homogeneity and genetical basis of TouretteÕs syndrome regardless of geographical region and ethnic origin
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Transtornos de Tique / Síndrome de Tourette Limite: Adolescente / Adulto / Criança, pré-escolar / Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Chile Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 1999 Tipo de documento: Artigo
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Transtornos de Tique / Síndrome de Tourette Limite: Adolescente / Adulto / Criança, pré-escolar / Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Chile Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 1999 Tipo de documento: Artigo
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