Plasmodium yoelii: identification of a gene encoding a putative ADP-ribosylation factor-1 GTPase-activating protein, PyAG1
Mem. Inst. Oswaldo Cruz
; 95(3): 345-52, May-Jun. 2000. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-258188
Biblioteca responsável:
BR1.1
ABSTRACT
The PyAG1 gene, identified by the screening of a Plasmodium yoelii genomic DNA library with a rhoptry-specific Mab, encodes a protein with a zinc finger structure immediately followed by the consensus sequence of the Arf GAP catalytic site. The serum of mice immunized with the recombinant protein recognized specifically the rhoptries of the late infected erythrocytic stages. Blast analysis using the Genbank database gave the highest scores with four proteins presenting an Arf1 GAP activity. If presenting also this activity, the PyAG1 protein could be involved in the regulation of the secreted protein vesicular transport and, consequently, in the rhoptry biogenesis.
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Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Plasmodium yoelii
/
Genes de Protozoários
/
Fator 1 de Ribosilação do ADP
/
Proteínas Ativadoras de GTPase
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
Medicina Tropical
/
Parasitologia
Ano de publicação:
2000
Tipo de documento:
Artigo