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Tratamiento del hipertiroidismo con radioyodo: efecto de la dosis administrada sobre la función tiroidea y complicaciones asociadas / Treatment of hyperthyroidism with radioiodine: effects of administered dose on complications and thyroid function
Pineda B., Pedro; Michelsen D., Harold; Rivera Carrillo, Marcela; Lillo Ganter, Ricardo; Massardo Vega, Teresa; Araya Q., Verónica; Sierralta C., Paulina; Oviedo G., Sofía; Liberman Guendelman, Claudio.
Afiliação
  • Pineda B., Pedro; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Michelsen D., Harold; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Rivera Carrillo, Marcela; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Lillo Ganter, Ricardo; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Massardo Vega, Teresa; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Araya Q., Verónica; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Sierralta C., Paulina; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Oviedo G., Sofía; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
  • Liberman Guendelman, Claudio; Universidad de Chile. Hospital Clínico. Departamento de Medicina. Sección Endocrinología.
Rev. méd. Chile ; 128(5): 499-507, mayo 2000. tab, graf
Artigo em Espanhol | LILACS | ID: lil-267660
Biblioteca responsável: CL1.1
RESUMO

Background:

Radio-iodine is a definite therapy for Graves disease hyperthyroidism. However, the optimal dosage is still debatable.

Aim:

To assess the effects of different radioiodine doses on thyroid function and complications in patients with hyperthyroidism. Material and

methods:

A retrospective analysis of 139 patients with hyperthyroidism, treated with ratioiodine between 1988 and 1998. Radio iodine dose used was classified as low (<10 mCi), intermediate (10-14.9 mCi) or high (ü 15 mCi).

Results:

Thirty five patients were treated with low doses, 33 with intermediate doses and 71 with high doses. There were no differences between these patients in age, disease severity, frequency of post treatment euthyroidism or complications. Patients treated with low doses had a higher frequency of persistent hyperthyroidism than patients treated with high doses (25.7 and 4.2 percent respectively, p<0,001). Likewise, the frequency of subsequent hypothyroidism was 60 percent in patients treated with low doses and 84.5 percent of those with high doses, in whom it also appeared earlier. Associated complications were clinically irrelevant. In seven patients, Graves ophtalmopathy progressed after treatment, but this progression was not associated with the dose used.

Conclusions:

Radio iodine in high doses is useful, safe and effective for the treatment of Graves hyperthyroidism
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Hipertireoidismo / Radioisótopos do Iodo Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Hipertireoidismo / Radioisótopos do Iodo Limite: Adolescente / Adulto / Feminino / Humanos / Masculino Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo
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