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A randomised bouble-blind placebo controlled trial of lidamidine HCL in irritable vowel syndrome
Awad, R. A; Llorens, F; Camelo, Ana Lilia; Sánchez, María.
Afiliação
  • Awad, R. A; Ministry of Health of Mexico City. General Hospital. Experimental Medicine and Motility Unit.
  • Llorens, F; Ministry of Health of Mexico City. General Hospital. Experimental Medicine and Motility Unit.
  • Camelo, Ana Lilia; Ministry of Health of Mexico City. General Hospital. Experimental Medicine and Motility Unit.
  • Sánchez, María; Ministry of Health of Mexico City. General Hospital. Experimental Medicine and Motility Unit.
Acta gastroenterol. latinoam ; 30(3): 169-75, jul. 2000. tab, graf
Artigo em Inglês | LILACS | ID: lil-269921
Biblioteca responsável: BR1.1
RESUMO

BACKGROUND:

We have previously shown electro-mechanical recto-anal alterations in irritable bowel syndrome patients (Awad R. Neurogastroenterol Motil 1993; 5; 265-271). To assess whether the alpha 2-agonist lidamidine HCL is able to modify these physiological alterations and alleviate clinical symptoms, 50 patients with irritable bowel syndrome were studied in a random, double blind, placebo-controlled trial.

METHODS:

Lidamidine HCL (4 mg) or placebo was taken orally t.i.d. with food. Fasting and post-prandial electrical and mechanical activities of rectum and internal anal sphincter were recorded before and at the end of treatment. Recto-anal sensitivity was also tested.

RESULTS:

After treatment, post-prandial duration of spontaneous recto-anal inhibitory reflex diminished in the lidamidine group (18.9 +/- 1 vs. 15.1 +/- 1.3 sec; p < 0.05). Amplitude of induced rectoanal inhibitory reflex decreased after lidamidine (24.6 +/- 2.9 vs 17.3 +/- 3 mmHg; p = 0.02). Rectal electrical activity showed no changes during basal and post-prandial periods in any group. Rectal painful sensation decreased after treatment with lidamidine (54.8 +/- 5.4 vs 43.6 +/- 3.5 ml; p < 0.05) as well as with placebo (p < 0.05). Abdominal distension and requency, severity and duration of pain diminished in both groups (p < 0.05).

CONCLUSION:

Lidamidine decreased the augmented mechanical response to food, reduced rectal sensitivity, and relieved symptoms. These facts suggest that in spite of the strong placebo response obtained, lidamidine HCL can become a useful alternative for treatment of patients with irritable bowel syndrome.
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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Compostos de Fenilureia / Doenças Funcionais do Colo / Agonistas Adrenérgicos beta / Motilidade Gastrointestinal Tipo de estudo: Ensaio clínico controlado Limite: Adulto / Humanos Idioma: Inglês Revista: Acta gastroenterol. latinoam Assunto da revista: Gastroenterologia Ano de publicação: 2000 Tipo de documento: Artigo

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Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Compostos de Fenilureia / Doenças Funcionais do Colo / Agonistas Adrenérgicos beta / Motilidade Gastrointestinal Tipo de estudo: Ensaio clínico controlado Limite: Adulto / Humanos Idioma: Inglês Revista: Acta gastroenterol. latinoam Assunto da revista: Gastroenterologia Ano de publicação: 2000 Tipo de documento: Artigo
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