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Detection of human papillomavirus in epithelial lesions of the conjunctiva
Palazzi, Maristela Amaral; Erwenne, Clélia Maria; Villa, Luísa Lina.
Afiliação
  • Palazzi, Maristela Amaral; Universidade Federal de Säo Paulo. Escola Paulista de Medicina. Säo Paulo. BR
  • Erwenne, Clélia Maria; Universidade Federal de Säo Paulo. Escola Paulista de Medicina. Säo Paulo. BR
  • Villa, Luísa Lina; University de Säo Paulo. Faculda de Medicina. Säo Paulo. BR
Säo Paulo med. j ; 118(5): 125-30, Sept. 2000.
Artigo em Inglês | LILACS | ID: lil-271285
Biblioteca responsável: BR1.1
ABSTRACT
CONTEXT Many factors like exposure to UV radiation, climatic conditions, genetic predisposition, immunological state and, more recently, the presence of HPV have been implicated in the genesis of some lesions of the conjunctiva, especially the carcinoma.

OBJECTIVE:

To evaluate the presence of HPV DNA in acquired lesions of the conjunctiva and in normal mucosa. TYPE OF STUDY Cross-sectional study.

SETTING:

A public university referral center (the Ophthalmology Service of the A.C. Camargo Hospital - A. Prudente Foundation, Sao Paulo).

PARTICIPANTS:

Thirty patients with acquired lesions of the conjunctiva and 60 matched controls (by age and sex) were evaluated in this study, from June 1993 to March 1995. PROCEDURES The detection of HPV DNA in the normal conjunctiva and in acquired lesions was done by the PCR technique and dot blot hybridization. The material was collected by scraping the normal mucosa and the surface of the lesions. A fragment of fresh frozen tissue and paraffin embedded specimens of each lesion were also included. MAIN MEASUREMENTS The association between the HPV infection and the presence or absence of conjunctival lesions.

RESULTS:

Sequences of HPV DNA were detected in 4 of the 31 lesions evaluated (12.9 percent) and in the healthy mucosa of one individual of the control group (1.6 percent). HPV type 16 was detected in 2 carcinomas and in the normal mucosa of one individual of the control group. HPV type 11 was demonstrated in 2 papillomas of one patient with lesions in both eyes.

CONCLUSIONS:

The low frequency of HPV DNA found in the lesions of this sample and the detection of the viral genome in the normal mucosa indicate that there is a weak possibility of association between HPV infection and the carcinoma of the conjunctiva
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Papillomaviridae / Túnica Conjuntiva Tipo de estudo: Estudo de prevalência Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Säo Paulo med. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de Säo Paulo/BR / University de Säo Paulo/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Papillomaviridae / Túnica Conjuntiva Tipo de estudo: Estudo de prevalência Limite: Adolescente / Adulto / Criança / Feminino / Humanos / Masculino Idioma: Inglês Revista: Säo Paulo med. j Assunto da revista: Medicina Ano de publicação: 2000 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de Säo Paulo/BR / University de Säo Paulo/BR
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