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Leishmania (Leishmania) major-infected rhesus macaques (Macaca mulatta) develop varying levels of resistance against homologous re-infections
Amaral, V. F; Teva, A; Porrozzi, R; Silva, A. J; Pereira, M. S; Oliveira-Neto, M. P; Grimaldi Júnior, G.
Afiliação
  • Amaral, V. F; Fundaçäo do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro. BR
  • Teva, A; Fundaçäo do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro. BR
  • Porrozzi, R; Fundaçäo do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro. BR
  • Silva, A. J; Fundaçäo do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro. BR
  • Pereira, M. S; Fundaçäo do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro. BR
  • Oliveira-Neto, M. P; Fundaçäo do Instituto Oswaldo Cruz. Hospital Evandro Chagas. Rio de Janeiro. BR
  • Grimaldi Júnior, G; Fundaçäo do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro. BR
Mem. Inst. Oswaldo Cruz ; 96(6): 795-804, Aug. 2001. ilus, graf
Artigo em Inglês | LILACS | ID: lil-298618
Biblioteca responsável: BR1.1
ABSTRACT
Seven rhesus macaques were infected intradermally with 10(7) promastigotes of Leishmania (Leishmania) major. All monkeys developed a localized, ulcerative, self-healing nodular skin lesion at the site of inoculation of the parasite. Non-specific chronic inflammation and/or tuberculoid-type granulomatous reaction were the main histopathological manifestations of the disease. Serum Leishmania-specific antibodies (IgG and IgG1) were detected by ELISA in all infected animals; immunoblot analyses indicated that numerous antigens were recognized. A very high degree of variability was observed in the parasite-specific cell-mediated immune responses [as detected by measuring delayed-type hypersensitivity (DTH) reaction, in vitro lymphocyte proliferation, and gamma interferon (IFN-gamma) production] for individuals over time post challenge. From all the recovered monkeys (which showed resolution of the lesions after 11 weeks of infection), 57.2 percent (4/7) and 28.6 percent (2/7) animals remained susceptible to secondary and tertiary infections, respectively, but the disease severity was altered (i.e. lesion size was smaller and healed faster than in the primary infection). The remaining monkeys exhibited complete resistance (i.e. no lesion) to each rechallenge. Despite the inability to consistently detect correlates of cell-mediated immunity to Leishmania or correlation between resistance to challenge and DTH, lymphocyte transformation or IFN-gamma production, partial or complete acquired resistance was conferred by experimental infection. This primate model should be useful for measuring vaccine effectiveness against the human disease
Assuntos
Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Leishmaniose Cutânea / Leishmania major Limite: Animais Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Fundaçäo do Instituto Oswaldo Cruz/BR

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Leishmaniose Cutânea / Leishmania major Limite: Animais Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Assunto da revista: Medicina Tropical / Parasitologia Ano de publicação: 2001 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Fundaçäo do Instituto Oswaldo Cruz/BR
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