Neutralizing antibodies to Enterovirus 71 in Belém, Brazil
Mem. Inst. Oswaldo Cruz
; 97(1): 47-49, Jan. 2002. graf
Article
em En
| LILACS
| ID: lil-306077
Biblioteca responsável:
BR1.1
ABSTRACT
Non-polio enteroviruses (Coxsackievirus A, Coxsackievirus B, Echovirus and EV 68-72) which belong to the enterovirus (EV) genus, Picornaviridae family, may be responsible for acute flaccid paralysis, aseptic meningitis, myocarditis, hepatitis, pleurodinia, neonatal sepsis, hand, foot and mouth disease (HFMD) even though 50-80 percent of infections are asymptomatic. EV 71 has been responsible for outbreaks and epidemics of HFMD and acute neurologic disease justifying its study in our country. The aim of this study was to detect neutralizing antibodies (NtAb) to EV 71 in individuals up to 15 years of age living in Belém, State of Pará, northern Brazil. Serum samples from 238 patients attending the Virology Sector of Evandro Chagas Institute in Belém, Brazil, were analyzed using microneutralization tests that included RD cells and BrCr strain. Overall 40.8 percent (97/238) of tested samples had NtAb to EV 71. Regarding the distribution per age group, 85.2 percent (92/108) of patients aged 0-3 years had no NtAb to this virus and 69.2 percent of those 12 to15 years of age were seropositive. These results confirm that EV 71 infection occurs in the city of Belém; and that a high rate of individuals in this study were infected aged 3 years and over and, when aged 15 years nearly 70 percent had EV 71 NtAb
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Enterovirus
/
Anticorpos Antivirais
Limite:
Adolescent
/
Child
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Child, preschool
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Female
/
Humans
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Infant
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Male
/
Newborn
País/Região como assunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Assunto da revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Brasil