Influência do acréscimo de manitol à solução nutriente no desempenho mecânico e no grau de edema miocárdico de coraçoes isolados de ratos / Influence of Mannitol Added to the Perfusion Solution on Mechanical Properties and Myocardial Edema of Isolated Rat Hearts
Arq. bras. cardiol
; 64(3): 225-229, Mar. 1995.
Artigo
em Português
| LILACS
| ID: lil-319700
Biblioteca responsável:
BR1.1
ABSTRACT
PURPOSE--To analyse the influence of mannitol added to Krebs-Henseleit (KH) solution on the myocardium edema and myocardial function. METHODS--Isolated rat heart under isovolumetric contractions studied according to Langendorff's technique were perfused with KH solution at constant flow during 90 min. The coronary perfusion pressure, diastolic and systolic pressures were recorded at every 15 min. At the end of the experiment, myocardium water content was measured in hearts perfused with KH solution (group I, n = 9) and in hearts perfused with KH solution plus 8mM mannitol (group II, n = 8). These results were compared to non-perfused control heart (n = 9). RESULTS--Myocardial water content was statistically higher in group I (80.8 +/- 1.3) compared to group II (78.1 +/- 0.7) and control group (75.5 +/- 0.5). Systolic arterial pressure was statistically higher in group I (86.2 +/- 11.5mmHg) compared to group II (72.7 +/- 21.1mmHg). There was no difference in the diastolic pressure between the two groups. Coronary perfusion pressure (Pp) increased progressively during the experiment in both groups. However, Pp was lower in group II than in group I. CONCLUSION--Mannitol added to KH solution significantly attenuates the myocardium edema in the isolated perfused rat heart.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Técnicas In Vitro
/
Soluções Cardioplégicas
/
Diuréticos Osmóticos
/
Edema Cardíaco
/
Manitol
/
Contração Miocárdica
Limite:
Animais
Idioma:
Português
Revista:
Arq. bras. cardiol
Assunto da revista:
Cardiologia
Ano de publicação:
1995
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual Paulista (UNESP)/BR