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Seropositivity for anti-trypanosoma cruzi antibodies among blood donors of the "Hospital Universitário Regional do Norte do Paraná", Londrina, Brazil
Rev. Inst. Med. Trop. Säo Paulo ; 38(3): 233-240, May-Jun. 1996.
Artigo em Inglês | LILACS | ID: lil-320639
Biblioteca responsável: BR1.1
The most frequent form of acquisition of Chagas' disease in endemic areas was the transmission through the feces of contaminated triatominae. However, special attention should be paid in urban areas to transmission by blood transfusion, justifying the compulsory screening of blood donors. Early investigations at blood banks in the town of Londrina, Brazil, demonstrated that the seroprevalence of anti-Trypanosoma cruzi antibodies among blood donors was approximately 7.0 in the fifties. Further studies demonstrated practically the same seroprevalence until the eighties. In an attempt to obtain data about the real dimension of the seropositivity for anti-Trypanosoma cruzi antibodies in the region, the authors carried out a large-scale study on 45,774 serum samples from blood donors of the Hemocentro of Hospital Univesitário Regional do Norte do Paraná (HURNP), Universidade Estadual de Londrina. The immunological tests were done at the Division of Clinical Immunology of HURNP from May 1990 to December 1994. The serum samples were studied by the indirect hemagglutination assay (IHA, using kits commercially obtained from EBRAM) and by indirect immunofluorescence (IFI, using kits from LIO SERUM) with anti-human IgG conjugate (LABORCLIN). The results demonstrated that 643 serum samples were positive in both assay corresponding to a seroprevalence of 1.4, i.e., a significant decrease in anti-Trypanosoma cruzi antibodies in the region in comparison with the previously mentioned rates. Data correlating sex and age of seropositive blood donors are presented, as well as the possible factors that may have contributed to the results observed.





Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Trypanosoma cruzi / Doadores de Sangue / Anticorpos Antiprotozoários / Doença de Chagas Aspecto clínico: Prognóstico Limite: Animais / Feminino / Humanos / Masculino País/Região como assunto: América do Sul / Brasil Idioma: Inglês Revista: Rev. Inst. Med. Trop. Säo Paulo Assunto da revista: Medicina Tropical Ano de publicação: 1996 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Estadual de Londrina/BR