Evaluation of the effect of hyoscine-N-butyl bromide on the cardiovascular actions of detomidine in the horse
Braz. j. vet. res. anim. sci
; 37(5): 405-409, 2000. ilus, tab
Article
em En
| LILACS
| ID: lil-327438
Biblioteca responsável:
BR68.1
ABSTRACT
Twenty one adult horses, males and females, were pretreated with 0.14 mg/kg of hyoscine-N-butylbromide intravenously and injected 5 minutes later with 0.02 mg/kg, iv of detomidine (group A, n = 9) or saline (group B, n = 12). Mean arterial pressure measurements and electrocardiography were performed during 65 minutes. After hyoscine injection the heart rate was increased by 43 percent and 65 percent in A and B groups, respectively. Heart rate remained increased after injection of detomidine, returning to baseline values after 15 minutes. No increase in the mean arterial pressure (MAP) was noticed after hyoscine but the MAP was increased by 62 percent after detomidine, returning to basal measurements until the end of observation time. No additional increase was noted in the group B horses. Hyoscine shortened PR and QT intervals in both groups, but after detomidine, PR and QT intervals enlarged significantly at the end of the experiment. The second degree atrioventricular block occurred in 3 horses after 40 minutes only in group B. It was concluded that hyoscine prevented detomidine induced bradycardia and may be an useful drug combination against the bradycardia induced by this alpha-2 agonist, in horses
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Escopolamina
/
Cavalos
Limite:
Animals
Idioma:
En
Revista:
Braz. j. vet. res. anim. sci
Assunto da revista:
MEDICINA VETERINARIA
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Brasil
País de publicação:
Brasil